Mystic Manor is much more fantastical/whimsical than anything so far in Animal Kingdom. Animal kingdom is mostly grounded in legitimate but sometimes fun presentations of animals, species, or culture. Mystic Manor is largely fictional/mystical and unlike Pandora doesn't have a larger world to build off of for placemaking.
You could theoretically turn it into more of a museum ride, where the artifacts presented are legitimately from locations like SEA, but you'd have to strip away much of the premise (magic music box, adventure monkey, etc) in order to make it feel cohesive. It's a cool experience, but not suitable for Animal Kingdom.