I doubt it. The debate moderator is not going to be constantly hammering DeSantis with questions about this while they ask more "legitimate" questions to the other candidates. DeSantis will no doubt have the same opportunity to opine on China, Russia, geopolitics, etc. as the other candidates.
This is assuming this topic is a negative for him, which is not a foregone conclusion.
DeSantis won re-election in a landslide after he started fighting with Disney. This was in a formerly purple state and he even won Miami-Dade County. Social media, which does not represent the average voter, may get a kick out of all this legal maneuvering and King Charles and all that stuff, but DeSantis seems to have connected with voters who don't normally vote Republican by standing against values these voters think are too far-left. There's a chance he may do it nationally and you might miss it if you only hang out on social media, Reddit and pro-Disney echo chambers.
And if DeSantis does make it out of the primary, it's not going to matter what push polls say about Americans being so aghast over what DeSantis has done in Florida. What matters in presidential politics is what a relatively small handful of voters in swing states think and online chatter does not generally reflect what they think.
And this is a guy that turned a swing state dark red.