Onward should get a complete pass as it was released on March 6th, 2020,
But Lightyear is a valid comparison, even though it's Pixar. Strange World is the last movie to be released from Walt Disney Animation Studios, so it's a more fair comparison for the studio. Here's what those opening weekends looked like, on their way to losing hundreds of millions of dollars combined at the box office for Disney...
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Obviously Wish will not do as disastrously as Strange World did. That failure was historical in nature, and ranks up there with Ishtar or West Side Story '22 as a money losing offering.
But the comparison to Lightyear is more accurate financially. If Wish only gets the same $50 Million opening weekend that Lightyear got, and thus only has $220 Million or so in global box office six weeks later, that would mean Wish would lose about $180 Million for Disney.
Wish simply needs to overperform on current projections its opening weekend, and then have good word of mouth and have legs that last until Christmas. Otherwise, it's losing money. Perhaps a great deal of money.