Covid Vaccine Updates and General Discussion About Vaccines

[Heppenheimer]

That’s why the companies producing the vaccines said immunity lasts 6 months, because that’s the longest data they have. They were not saying it only lasts 6 months and then is gone they were saying it lasts at least 6 months based on the phase 1/2 trial participants and as time goes on we will see how much longer it lasts. You are jumping to the conclusion that it will only last 6 months, but there is no current data to support that. For natural infections there are studies out of China that people who were infected Jan/Feb are still showing signs of immune response almost a year later. Immune response from vaccination should in theory be as good or better than natural infection.

We also have over a century of experience learning how to engineer more strongly enduring immunity from vaccines than from the natural response.

 

[correcaminos]

The reality is the vaccine test subjects were only given the vaccines in the summer so there hasn't been anyway to even check for the presence of antibodies in someone 6 months after they were vaccinated.

Phase 1 has 6 months already as an FYI. I was called to get phase 3 in July. Due to scheduling conflicts I was Sept when originally I should've been Aug.

 

[GoofGoof]

Novavax becomes 5th company to reach a stage 3 trial in the US for a Covid 19 vaccine. If the trial is successful they could be ready to apply for EUA by the end of Q1 2021. The US purchased 100M doses of the initial rollout so another backup plan in case Oxford or JnJ doesn’t come through.

Novavax starts late-stage trial of COVID-19 vaccine in United States

Novavax Inc has begun a large late-stage study of its experimental COVID-19 vaccine in the United States, the drug developer said on Monday, after delaying the trial twice due to issues in scaling up the manufacturing process. It will enroll up to 30,000 volunteers across about 115 sites in the...

news.yahoo.com

 

[HongKongFooy]

Well one of those vaccines definitely should not be distributed and ultimately injected in Beverly Hills, Santa Monica, Malibu, Bel Aire and the like...

 

[GoofGoof]

AstraZeneca vaccine is expected to be approved in the UK as early as Thursday with the first vaccinations starting Jan 4. The CEO claims they have figured out the winning formula to get the efficacy up to the same level as the Pfizer and Moderna vaccines. If true that’s a big deal. They expect to have 700 million doses worldwide manufactured by the end of March. The US trial is expected to have results in Jan and if the results are positive they expect to apply for EUA in early Feb. Warp Speed bought 300 million doses of this vaccine and AstraZeneca has a US based manufacturing site setup which started production in September.

AstraZeneca Covid vaccine has 'winning formula': CEO

The Covid-19 vaccine developed by the British drugs group AstraZeneca and the University of Oxford has achieved a "winning formula" for efficacy, the company's chief executive said on Sunday.

news.yahoo.com

 

[Disney Experience]

AstraZeneca vaccine is expected to be approved in the UK as early as Thursday with the first vaccinations starting Jan 4. The CEO claims they have figured out the winning formula to get the efficacy up to the same level as the Pfizer and Moderna vaccines. If true that’s a big deal. They expect to have 700 million doses worldwide manufactured by the end of March. The US trial is expected to have results in Jan and if the results are positive they expect to apply for EUA in early Feb. Warp Speed bought 300 million doses of this vaccine and AstraZeneca has a US based manufacturing site setup which started production in September.

AstraZeneca Covid vaccine has 'winning formula': CEO

The Covid-19 vaccine developed by the British drugs group AstraZeneca and the University of Oxford has achieved a "winning formula" for efficacy, the company's chief executive said on Sunday.

news.yahoo.com

The problem in the wording in the articles I have read so far can be summarized in that the CEO says they have a "winning formula". Drilling down there is still no published data refuting AstraZeneca mixed results in mass Phase 3 testing done to date. Statistically, the mistakes in dosage do not bring confidence in it having efficacy as good as Pfizer or Moderna's. But the CEO sounds confident that their vaccine will be. Either he has unpublished data (which would be an issue in itself), or he is just trying to be a cheerleader for his company's product.

It is still above the 50% low bar set by the USA's FDA. I am glad it will be out and in use in the UK soon. The ability of AstraZeneca to produce the vast quantities of vaccine needed is good. The price per dose is great. I just like clear facts from the companies, not cheerleading from their CEO that is not aligned with the facts they have so far published.

For example the article below headlines with "has up to" 90% efficacy, but reading the whole article you can see how that is only in the 1367 participants who got the incorrect first dose had 90% efficacy. This small (1367) sample space may have a lot of room for errors.
The 62% efficacy is what the people who got full doses achieved. So the mistake may be the winning formula. But for now the blended results is in the 70% range.

Phase 3 trials show AstraZeneca COVID vaccine has up to 90% efficacy

www.cidrap.umn.edu

 

[GoofGoof]

According to the below article the US government has exercised their option for an additional 100M doses of the Moderna vaccine bringing the total to 300M doses. The additional doses are scheduled to be delivered by June 30. When combined with Pfizer thats 500M doses by June/July timeframe or enough for 250M people (76% of the population) or almost every adult if they aren’t approved for children. I know the rollout isn’t going as fast as hoped but we are still on track for likely having anyone in the US who wants a vaccine inoculated by June/July at the latest. Keep the faith

U.S. Department of Defense Awards Moderna $1.97 Billion COVID-19 Vaccine Contract

The U.S. Department of Defense awarded Moderna a contract worth $1,966,598,000 for an additional 100 million doses of its COVID-19 vaccine.

www.biospace.com

 

[ToTBellHop]

According to the below article the US government has exercised their option for an additional 100M doses of the Moderna vaccine bringing the total to 300M doses. The additional doses are scheduled to be delivered by June 30. When combined with Pfizer thats 500M doses by June/July timeframe or enough for 250M people (76% of the population) or almost every adult if they aren’t approved for children. I know the rollout isn’t going as fast as hoped but we are still on track for likely having anyone in the US who wants a vaccine inoculated by June/July at the latest. Keep the faith

U.S. Department of Defense Awards Moderna $1.97 Billion COVID-19 Vaccine Contract

The U.S. Department of Defense awarded Moderna a contract worth $1,966,598,000 for an additional 100 million doses of its COVID-19 vaccine.

www.biospace.com

Ok, I will give the President credit where it is due: he throws money at problems which, in this case, is a good thing. However, they desperately need to start getting 2 million shots per day into arms (including the folks getting dose 2, which actually starts soon). 200k/day is not cutting it. We have the vaccines. We need funding and guidance to administer them. Telling states exactly how many doses they will receive each week and how many are Pfizer vs. Moderna would be a good start.

 

[networkpro]

Well one of those vaccines definitely should not be distributed and ultimately injected in Beverly Hills, Santa Monica, Malibu, Bel Aire and the like...

They are not afraid there to inject anything into any part of their bodies. So what's this class warfare stuff you're trying to inject into this situation? The Government purchased vaccines have their distribution controlled by the State governments. If there are vaccine doses available that are not part of that purchase, I'd bet that they are free market priced.

 

[ToTBellHop]

According to the below article the US government has exercised their option for an additional 100M doses of the Moderna vaccine bringing the total to 300M doses. The additional doses are scheduled to be delivered by June 30. When combined with Pfizer thats 500M doses by June/July timeframe or enough for 250M people (76% of the population) or almost every adult if they aren’t approved for children. I know the rollout isn’t going as fast as hoped but we are still on track for likely having anyone in the US who wants a vaccine inoculated by June/July at the latest. Keep the faith

U.S. Department of Defense Awards Moderna $1.97 Billion COVID-19 Vaccine Contract

The U.S. Department of Defense awarded Moderna a contract worth $1,966,598,000 for an additional 100 million doses of its COVID-19 vaccine.

www.biospace.com

Wonder why this isn’t being reported elsewhere. Can’t find it from any news agency.

 

[GoofGoof]

Wonder why this isn’t being reported elsewhere. Can’t find it from any news agency.

I couldn’t either. I was wondering originally if that was the 2nd 100M doses bought earlier in Dec but the article said it was in addition to the first 200M doses already bought. Moderna didn’t put out a press release either.

 

[1HAPPYGHOSTHOST]

I couldn’t either. I was wondering originally if that was the 2nd 100M doses bought earlier in Dec but the article said it was in addition to the first 200M doses already bought. Moderna didn’t put out a press release either.

GARSH! HI-YUCK

 

[correcaminos]

I couldn’t either. I was wondering originally if that was the 2nd 100M doses bought earlier in Dec but the article said it was in addition to the first 200M doses already bought. Moderna didn’t put out a press release either.

Just to add some light-heartedness... maybe everyone is sleeping and tired from the NYE parties (at home, so more drinking allowed since less driving) and they missed it?

I hope they pick up the pace. As stated the H1N1 was slow to go at first and I kind of expected the same for this tbh

 

[ToTBellHop]

GARSH! HI-YUCK

 

[GoofGoof]

Just to add some light-heartedness... maybe everyone is sleeping and tired from the NYE parties (at home, so more drinking allowed since less driving) and they missed it?

I hope they pick up the pace. As stated the H1N1 was slow to go at first and I kind of expected the same for this tbh

I hope so.

Now that it’s officially January all eyes on JnJ. Balls in your court now guys...3 vaccine candidates is better than 2

 

[ToTBellHop]

I hope so.

Now that it’s officially January all eyes on JnJ. Balls in your court now guys...3 vaccine candidates is better than 2

I understand JnJ data should be forthcoming within the next 3 weeks or so. They are rapidly seeing cases (but the data is still blinded, so it’s not clear which groups are seeing cases--placebo or vaccine).

No reason to expect unacceptable efficacy.

 

[MisterPenguin]

Ok, I will give the President credit where it is due: he throws money at problems

...except to the states on whom he puts the burden of distribution after their own resources have been depleted because of a pandemic...

 

[ToTBellHop]

...except to the states on whom he puts the burden of distribution after their own resources have been depleted because of a pandemic...

Indeed. And most states would find the funding anyway if they only had information. Not even knowing how many vaccines (and which type) they will receive is problematic.

I feel fortunate to live in a state where half the hospitals are owned by Yale and we have plenty of ultra-cold freezers.

 

[ToTBellHop]

I examined this more closely--it’s legitimate. I presume this story hasn’t gone wide because it’s a holiday week.

Original DoD contract dated 8/9/20 purchased 100,000,000 doses for $1.525 billion https://contracts.justia.com/companies/moderna-inc-5634/contract/135568/

Amended 12/28/20 purchasing a further 100,000,000 doses for $1.966 billion https://www.defense.gov/Newsroom/Contracts/Contract/Article/2457857/?source=content_type:react|first_level_url:news|section:main_content|button:body_link

Separate purchase of 100,000,000 doses on 12/11/20 for $1.68 billion (widely reported)

300,000,000 doses from Moderna by June 30 purchased for $5.17 billion
200,000,000 doses from Pfizer by July 31 purchased for $3.9 billion

 

[JoeCamel]

I examined this more closely--it’s legitimate. I presume this story hasn’t gone wide because it’s a holiday week.

Original DoD contract dated 8/9/20 purchased 100,000,000 doses for $1.525 billion https://contracts.justia.com/companies/moderna-inc-5634/contract/135568/

Amended 12/28/20 purchasing a further 100,000,000 doses for $1.966 billion https://www.defense.gov/Newsroom/Contracts/Contract/Article/2457857/?source=content_type:react|first_level_url:news|section:main_content|button:body_link

Separate purchase of 100,000,000 doses on 12/11/20 for $1.68 billion (widely reported)

300,000,000 doses from Moderna by June 30 purchased for $5.17 billion
200,000,000 doses from Pfizer by July 31 purchased for $3.9 billion

They still have a purchase agreement with AstraZeneca for a bunch as well. Just need all of it delivered and in arms