From here..
America’s defense against epidemics is divided among more than 2,000 individual public-health departments, which makes implementing a national strategy very difficult.
www.theatlantic.com
In the U.S., quarantine is the most extreme use of government power over people who have committed no crime. As a legal matter, the U.S. Supreme Court recognized a seemingly unlimited local power to quarantine as early as 1824, in the case Gibbons v. Ogden. It reaffirmed this power in 1900, noting that “from an early day the power of the States to enact and enforce quarantine laws for the safety and the protection of the health of their inhabitants … is beyond question.”
Government officials can prevent travel, require vaccinations, make people submit to medical exams, and commandeer private property. Even those who are not sick can be ordered into quarantine—confined to their home or another location with others who may also have been exposed to a virus. When quarantine is medically justified, individual rights give way to the greater good. As the Court stated in Jacobson v. Massachusetts in 1905, “Upon the principle of self-defense, of paramount necessity, a community has the right to protect itself against an epidemic of disease which threatens the safety of its members.” The constitutional structure tolerates such substantial restriction of liberties for at least a limited time in a true public-health emergency. That said, constitutional protections during quarantine do exist. For example, health officials must use the least restrictive means consistent with medical guidance, and the government must have good reason to believe you’ve been exposed.
If any body thinks this current Supreme Court isn't going to back expansive presidential powers in a crisis... you've not been paying attention.
And yes, you'll find quotes arguing the opposite, but they're from scholars and people who argue the government
shouldn't have such powers. Which is, in effect, acknowledging that the government does indeed have such powers.