Coronavirus and Walt Disney World general discussion

[jmp85]

I continue to say that an incentive is needed (and soon) for the under 40 population to get them vaccinated if we want to get to herd immunity. There is a huge percentage of people in the under 40 demographic (regardless of race, ethnicity or political views) who just aren't motivated to get the shot. They aren't anti-COVID vaccine but they really don't care if they get infected and don't want to be bothered getting vaccinated.

Maybe it can become a thing to post videos on Tic Tok of getting your COVID shot? I'm too old to know what appeals to people in their 20s anymore.

I agree that many in this group are apathetic about getting vaccinated. Oddly enough, I have two friends in their 30s with very serious health conditions and neither has received the vaccine. Both told me they thought the whole thing was overblown. To make it even stranger, they are both die-hard liberals.

 

[correcaminos]

I continue to say that an incentive is needed (and soon) for the under 40 population to get them vaccinated if we want to get to herd immunity. There is a huge percentage of people in the under 40 demographic (regardless of race, ethnicity or political views) who just aren't motivated to get the shot. They aren't anti-COVID vaccine but they really don't care if they get infected and don't want to be bothered getting vaccinated.

Maybe it can become a thing to post videos on Tic Tok of getting your COVID shot? I'm too old to know what appeals to people in their 20s anymore.

Anecdotally here parents are helping drive that. Know a few 30-somethings who got it because their mom told them to lol. Though I have a lot of 30 something friends who are on it themselves. Lots of 16-22 whose parents just booked them. They aren't anti covid shot as you said but didn't see the need. As more of my friends got appointments also, more who were "meh" thought they should as well. Kinda funny to watch sorta peer pressure take place.

 

[MisterPenguin]

Getting there wasn't the problem. Getting an appointment was. On the west coast too. They finally finished their 2nd dose. I got my husband a no waste dose in Ohio before they got their 1st shot.

I've helped enough loved ones in FL. Spent hours at a time sometimes to help. The ability to book was the road block.

This need to be kept in mind: That opening up vaccinations to "everyone" isn't as rosy as it sounds.

When the pool of available recipients was limited, many many places around the U.S. found that it took weeks and weeks to make an appointment.

Now that states are opening the pool to "everyone," that will only get worse. Many will find it will take a month to find an appointment to get a shot.

Watch in the coming weeks for constant complaints from a much larger swath of people that they can't make an appointment.

Enough doses for everyone will be at the end of May. Until then, getting an appointment will be an internet-hammering pastime for the next six weeks.

 

[GoofGoof]

This need to be kept in mind: That opening up vaccinations to "everyone" isn't as rosy as it sounds.

When the pool of available recipients was limited, many many places around the U.S. found that it took weeks and weeks to make an appointment.

Now that states are opening the pool to "everyone," that will only get worse. Many will find it will take a month to find an appointment to get a shot.

Watch in the coming weeks for constant complaints from a much large swath of people that they can't make an appointment.

Enough doses for everyone will be at the end of May. Until then, getting an appointment will be an internet-hammering pastime for the next six weeks.

I’m fine with this. The bigger issue is within states demand isn’t evenly distributed so it’s better to not have areas where appointments go unused even if that means in other areas it’s still near impossible to find one. Frustrating for the people in high demand areas, I know from experience, but better than having doses sit around unused. At some point states will need to further adjust distributions to counties or towns that have higher demand but for now they just continue to make more people eligible.

 

[SamusAranX]

What I want to know is why WHO says Ivermectin reduces mortality by 81% and decreases hospitalizations by 64% in the test patients, but they refuse to endorse it.

 

[JoeCamel]

What I want to know is why WHO says Ivermectin reduces mortality by 81% and decreases hospitalizations by 64% in the test patients, but they refuse to endorse it.

Why You Should Not Use Ivermectin to Treat or Prevent COVID-19

Using the Drug ivermectin to treat COVID-19 can be dangerous and even lethal. The FDA has not approved the drug for that purpose.

www.fda.gov

 

[Heppenheimer]

What I want to know is why WHO says Ivermectin reduces mortality by 81% and decreases hospitalizations by 64% in the test patients, but they refuse to endorse it.

They recommended against using it because the few actual trials published were observational and lacked placebo control. And ivermectin is not exactly a benign medication. Even Merck, who makes the drug, said its own analysis "did not support the drug's safety and efficacy for COVID-19".

The WHO did say, however, that they encouraged proper trials to assess these questions.

 

[DisneyCane]

Anecdotally here parents are helping drive that. Know a few 30-somethings who got it because their mom told them to lol. Though I have a lot of 30 something friends who are on it themselves. Lots of 16-22 whose parents just booked them. They aren't anti covid shot as you said but didn't see the need. As more of my friends got appointments also, more who were "meh" thought they should as well. Kinda funny to watch sorta peer pressure take place.

For once peer pressure is a good thing! I do my part. Any of my friends or acquaintances who are eligible but haven't tried to get an appointment, I push them to get motivated. I booked an appointment for my brother (first shot today) because he procrastinates so much on everything.

 

[danlb_2000]

What I want to know is why WHO says Ivermectin reduces mortality by 81% and decreases hospitalizations by 64% in the test patients, but they refuse to endorse it.

According the WHO's web site they data currently available is not conclusive on it's benefits. The EU and FDA also don't recommend it's use.

WHO advises that ivermectin only be used to treat COVID-19 within clinical trials

www.who.int

 

[SamusAranX]

They recommended against using it because the few actual trials published were observational and lacked placebo control. And ivermectin is not exactly a benign medication. Even Merck, who makes the drug, said its own analysis "did not support the drug's safety and efficacy for COVID-19".

The WHO did say, however, that they encouraged proper trials to assess these questions.

Thanks for the additional context. Reading that today, it was rather confusing.

 

[Nubs70]

Off for Round 2 of Pfizer

 

[mmascari]

So far all study results that have been released show Pfizer and Moderna being very similar. I'd be curious to know what is different about the two vaccines. I think, at the end of the day, they both do the same thing; use mRNA to get your cells to produce the spike protein of SARS-CoV-2. I know there are some differences in the ingredients between the two. There must also be some other difference since Pfizer's second shot is after 3 weeks and Moderna after 4. So far, every time the two are studied in a similar manner they provide similar protection.

I would guess the mRNA delivery mechanism is different. Same reason that one of them needed to be colder than the other. Assuming they are both generating to the same spike protein DNA, it's the way it's delivered and the delivery impact on the response that's probably the biggest difference.

The 3 vs 4 weeks is probably something more mundane. Something like in initial analysis they found one dose wasn't enough and some researcher thought 3 or 4 weeks was good so they tested that. Saw better results and then did the next test with the same value. Making the choice just a guess at the start, and it became the plan because that's what they tested then.

Just like all the questions about if we could wait 2 months instead of 1 and the guidance that we should stick with 1. It's all based on what was tested. We stick with 1 month because that's what the test data showed worked and there isn't test data for longer. Maybe longer would work, maybe not. Nobody will know unless they study it. But, there's no driver to test it, since we already tested 1 month and have working results.

Reading drug approval history is full of mundane things like that. All kinds of stuff based on historic performance and not current comparative analysis of different plans. Even more fun, lots of that original plan is just because that's the one someone tried, also not because of a comparative analysis.

 

[GoofGoof]

Vaccine update through the end of March:

Pfizer and Moderna came pretty close to their Q1 targets on manufacturing. JnJ came up short but they are expected to deliver about 12M doses next week so not too far off on the timing. I have no idea what the true impact of the manufacturing plant issue is but we know about 15M doses worth of vaccine that would have been delivered in April had to be destroyed so I assumed a 15M decrease in April deliveries from JnJ. Could be worse, could be better.

On vaccinations 74% of 65+ at least started is a great number and climbing. Almost 40% of all adults have started. If we keep up the pace we are on track to have 75% of adults and just under 60% of the general population starting their vaccinations by May 1. That‘s where Israel is today and their cases are in free fall

 

[Heppenheimer]

So far all study results that have been released show Pfizer and Moderna being very similar. I'd be curious to know what is different about the two vaccines. I think, at the end of the day, they both do the same thing; use mRNA to get your cells to produce the spike protein of SARS-CoV-2. I know there are some differences in the ingredients between the two. There must also be some other difference since Pfizer's second shot is after 3 weeks and Moderna after 4. So far, every time the two are studied in a similar manner they provide similar protection.

I dimly remember reading something about this months ago, but I may have misunderstood or I'm remembering it wrong, so don't take this as gospel.

But I believe each vaccine dose contains sets of slightly different mRNA sequences. This allows for transcribing some of the differences in spike protein composition that were known at the time they designed the vaccines. Pzifer and Moderna may have decided to include different proportions of the various mRNA sequences in their respective vaccines.

In retrospect, this might be why their vaccines have performed so well against the variants.

 

[danlb_2000]

I dimly remember reading something about this months ago, but I may have misunderstood or I'm remembering it wrong, so don't take this as gospel.

But I believe each vaccine dose contains sets of slightly different mRNA sequences. This allows for transcribing some of the differences in spike protein composition that were known at the time they designed the vaccines. Pzifer and Moderna may have decided to include different proportions of the various mRNA sequences in their respective vaccines.

In retrospect, this might be why their vaccines have performed so well against the variants.

Are you talking about difference between the two vaccines, or the two doses of the same vaccine? Everything I read said that both doses of a single vaccine are the same.

 

[mmascari]

Are you talking about difference between the two vaccines, or the two doses of the same vaccine? Everything I read said that both doses of a single vaccine are the same.

Pfizer vs Moderna

 

[DCBaker]

Numbers are out - there were 69 new reported deaths, along with 2 Non-Florida Resident deaths.

 

[Incomudro]

Just found out today that a former coworker of mine passed away from covid.
I still think of the guy as around 55 years of age, which is how old he was when I last saw him and he retired.
Turns out he was 69.
Time flies.
Rest in peace Gene.

 

[DCBaker]

Current Florida vaccine report -

 

[Heppenheimer]

Are you talking about difference between the two vaccines, or the two doses of the same vaccine? Everything I read said that both doses of a single vaccine are the same.

The differences between the two manufacturers... but I should point out, I don't know for a fact that they included different proportions of the various mRNA molecules, or even if they included any identical sequences in their respective vaccines. This could be a way their vaccines differ, but that doesn't mean it's necessarily the case.