Anecdotally here parents are helping drive that. Know a few 30-somethings who got it because their mom told them to lol. Though I have a lot of 30 something friends who are on it themselves. Lots of 16-22 whose parents just booked them. They aren't anti covid shot as you said but didn't see the need. As more of my friends got appointments also, more who were "meh" thought they should as well. Kinda funny to watch sorta peer pressure take place.
I’m fine with this. The bigger issue is within states demand isn’t evenly distributed so it’s better to not have areas where appointments go unused even if that means in other areas it’s still near impossible to find one. Frustrating for the people in high demand areas, I know from experience, but better than having doses sit around unused. At some point states will need to further adjust distributions to counties or towns that have higher demand but for now they just continue to make more people eligible.
They recommended against using it because the few actual trials published were observational and lacked placebo control. And ivermectin is not exactly a benign medication. Even Merck, who makes the drug, said its own analysis "did not support the drug's safety and efficacy for COVID-19".
For once peer pressure is a good thing! I do my part. Any of my friends or acquaintances who are eligible but haven't tried to get an appointment, I push them to get motivated. I booked an appointment for my brother (first shot today) because he procrastinates so much on everything.
I would guess the mRNA delivery mechanism is different. Same reason that one of them needed to be colder than the other. Assuming they are both generating to the same spike protein DNA, it's the way it's delivered and the delivery impact on the response that's probably the biggest difference.
I dimly remember reading something about this months ago, but I may have misunderstood or I'm remembering it wrong, so don't take this as gospel.
Pfizer vs Moderna
The differences between the two manufacturers... but I should point out, I don't know for a fact that they included different proportions of the various mRNA molecules, or even if they included any identical sequences in their respective vaccines. This could be a way their vaccines differ, but that doesn't mean it's necessarily the case.
Pfizer and Moderna are different. One thing both had to do is deal with producing the spike protein without the rest of the virus. So in layman's term( I know @Heppenheimer is not a layman, but for the rest of us ) picture that the spikes are twisted yarn shaped into a spike and the yarn continues into the rest of the virial surface. Without that viral surface the spike "yarn" would quickly unravel. So Pfizer and Moderna tied some knots into the yarn that is the spike so that it does not unravel even when produced without the rest of the virus. They probably tied the knots in different places.
