Coronavirus and Walt Disney World general discussion

[MisterPenguin]

People forget where things were at BEFORE last March...

The Fed/Treasury “poofed” $7,000,000,000,000 of Monopoly money into existence in the last 18 months. Half was BEFORE the corona shutdowns.

Why? “Market softening”

When you live on steroids, you will crash. Inevitable.

There were signs that the Circus Maximus routine was coming to halt before this...which means the pain will not end soon. It was overdue...but not avoidable.

 

[GoofGoof]

If it can prevent cases from requiring hospitalization, then that's good.

But I guess if I were the public who hasn't had the vaccine I'd be like, nah, I'll wait for the good ones..

One thing to consider with JnJ is in their phase 1 trial it took up to 60 days for some of the trial participants to develop a high enough level of antibodies to protect against the virus. Because there is no second shot or booster it takes a little longer to become immune. The majority, if not all of the people in the vaccine group who got infected were infected before reaching 60 days since right now only half the trial participants are even at 2 months in. Another thing to consider is JnJ is running a simultaneous trial using 2 doses so it will be interesting to see if the 72% in the US goes up from there based on 2 doses. It’s likely that if the numbers are far better anyone getting the JnJ vaccine now will receive a booster later to make it more effective.

66% sounds bad compared to 95% but one of the trial sites was S. Africa and one was in Brazil. The numbers there were lower due to the variants. The US number was 72%. Still not great compared to 95% on paper but the key is 85% of those in the vaccine group who were infected did not have severe infection and of the 15% that did none were hospitalized or died. So the vaccine is still 100% effective at keeping you alive and out of the hospital. That’s a pretty good result.

I think the way this will be used is they will use the JnJ vaccine for the lower risk population. They will continue to use Pfizer and Moderna on the elderly and those with higher risks. There has been a major push to get essential workers vaccinated sooner and lots of sour grapes over not prioritizing them now so once this vaccine is approved it can be quickly rolled out to teachers and grocery store workers and factory workers and bus drivers who will only need to go 1 time and get 1 shot. It will be logistically easier to pass these doses out to a school or a grocery store chain or Amazon or FedEx to be used on all their employees. I imagine Disney could get in on it too. Have doses delivered for all their CMs. For anyone working in these places who is at higher risk they could still wait for mRNA vaccines but it’s probably not necessary. This one seems to be pretty good. You also always have the option of getting JnJ now and then still getting Pfizer or Moderna in the Summer when it’s readily available.

 

[Kevin_W]

Busy this morning, so I didn't have time to red the details. Was J&J just tested on 18-yr-olds and up?

 

[GoofGoof]

Busy this morning, so I didn't have time to red the details. Was J&J just tested on 18-yr-olds and up?

Yes

 

[jmp85]

One thing to consider with JnJ is in their phase 1 trial it took up to 60 days for some of the trial participants to develop a high enough level of antibodies to protect against the virus. Because there is no second shot or booster it takes a little longer to become immune. The majority, if not all of the people in the vaccine group who got infected were infected before reaching 60 days since right now only half the trial participants are even at 2 months in. Another thing to consider is JnJ is running a simultaneous trial using 2 doses so it will be interesting to see if the 72% in the US goes up from there based on 2 doses. It’s likely that if the numbers are far better anyone getting the JnJ vaccine now will receive a booster later to make it more effective.

66% sounds bad compared to 95% but one of the trial sites was S. Africa and one was in Brazil. The numbers there were lower due to the variants. The US number was 72%. Still not great compared to 95% on paper but the key is 85% of those in the vaccine group who were infected did not have severe infection and of the 15% that did none were hospitalized or died. So the vaccine is still 100% effective at keeping you alive and out of the hospital. That’s a pretty good result.

I think the way this will be used is they will use the JnJ vaccine for the lower risk population. They will continue to use Pfizer and Moderna on the elderly and those with higher risks. There has been a major push to get essential workers vaccinated sooner and lots of sour grapes over not prioritizing them now so once this vaccine is approved it can be quickly rolled out to teachers and grocery store workers and factory workers and bus drivers who will only need to go 1 time and get 1 shot. It will be logistically easier to pass these doses out to a school or a grocery store chain or Amazon or FedEx to be used on all their employees. I imagine Disney could get in on it too. Have doses delivered for all their CMs. For anyone working in these places who is at higher risk they could still wait for mRNA vaccines but it’s probably not necessary. This one seems to be pretty good. You also always have the option of getting JnJ now and then still getting Pfizer or Moderna in the Summer when it’s readily available.

Overall efficacy against severe cases 85%, with none recorded beyond 49 days post-vaccination. Zero hospitalizations or deaths in any of the vaccinated participants beyond 28 days post-vaccination.

I'm still excited for this to receive approval and get rolled out. This will still make a huge difference in getting back to some sense of 'normal' much faster.

 

[dreday3]

Overall efficacy against severe cases 85%, with none recorded beyond 49 days post-vaccination. Zero hospitalizations or deaths in any of the vaccinated participants beyond 28 days post-vaccination.

I'm still excited for this to receive approval and get rolled out. This will still make a huge difference in getting back to some sense of 'normal' much faster.

As I process reading all about this, it really is great news.
This will be a game changer for sure.

We have a lot to be excited about people!

 

[GoofGoof]

Overall efficacy against severe cases 85%, with none recorded beyond 49 days post-vaccination. Zero hospitalizations or deaths in any of the vaccinated participants beyond 28 days post-vaccination.

I'm still excited for this to receive approval and get rolled out. This will still make a huge difference in getting back to some sense of 'normal' much faster.

As I process reading all about this, it really is great news.
This will be a game changer for sure.

We have a lot to be excited about people!

Agreed. The biggest struggle may be convincing people to take the JnJ vacccine and not wait around for the others.

 

[dreday3]

Agreed. The biggest struggle may be convincing people to take the JnJ vacccine and not wait around for the others.

From posts I've been reading around social media - people are like "gimme what you got!"

Prevailing thought is they will get JnJ for now and get the others when available if they want...

 

[GoofGoof]

From posts I've been reading around social media - people are like "gimme what you got!"

Prevailing thought is they will get JnJ for now and get the others when available if they want...

Good plan. As I said when Pfizer and Moderna were approved, I have 2 arms...I’ll take both. Now that there are 3 I have to move on to butt cheeks I guess

 

[Heppenheimer]

This is copied and pasted from another forum, so it might see more eyes:

Can anyone find a link to the actual official Johnson & Johnson trial (ENSEMBLE 2) paper? The other two vaccines had their results published in the New England Journal of Medicine, but I don't see any new information about ENSEMBLE 2 in the latest issue. The J&J website only contains a press release without any links to the actual trial. All the news reports seem to cover information in the press release, not necessarily the trial data.

 

[SamusAranX]

View attachment 527597

Reddit definitely said hold my beer and to hell with that

 

[oceanbreeze77]

Theres a group of people who are eager and will gladly take any shot, andJ&J proves itself to be a good shot.

But theres also already much resistance, its going to be hard to convince people who won't even take a shot with 95% efficacy, to take the J&J one. A common argument is "Why would I take a shot that's only 95% efficient in MAYBE preventing serious cases."

 

[Disney Experience]

One thing to consider with JnJ is in their phase 1 trial it took up to 60 days for some of the trial participants to develop a high enough level of antibodies to protect against the virus. Because there is no second shot or booster it takes a little longer to become immune. The majority, if not all of the people in the vaccine group who got infected were infected before reaching 60 days since right now only half the trial participants are even at 2 months in. Another thing to consider is JnJ is running a simultaneous trial using 2 doses so it will be interesting to see if the 72% in the US goes up from there based on 2 doses. It’s likely that if the numbers are far better anyone getting the JnJ vaccine now will receive a booster later to make it more effective.

66% sounds bad compared to 95% but one of the trial sites was S. Africa and one was in Brazil. The numbers there were lower due to the variants. The US number was 72%. Still not great compared to 95% on paper but the key is 85% of those in the vaccine group who were infected did not have severe infection and of the 15% that did none were hospitalized or died. So the vaccine is still 100% effective at keeping you alive and out of the hospital. That’s a pretty good result.

I think the way this will be used is they will use the JnJ vaccine for the lower risk population. They will continue to use Pfizer and Moderna on the elderly and those with higher risks. There has been a major push to get essential workers vaccinated sooner and lots of sour grapes over not prioritizing them now so once this vaccine is approved it can be quickly rolled out to teachers and grocery store workers and factory workers and bus drivers who will only need to go 1 time and get 1 shot. It will be logistically easier to pass these doses out to a school or a grocery store chain or Amazon or FedEx to be used on all their employees. I imagine Disney could get in on it too. Have doses delivered for all their CMs. For anyone working in these places who is at higher risk they could still wait for mRNA vaccines but it’s probably not necessary. This one seems to be pretty good. You also always have the option of getting JnJ now and then still getting Pfizer or Moderna in the Summer when it’s readily available.

The results of their two dose study efficacy will be interesting.

The efficacy of their single dose is greater than the efficacy of just the first dose of a two dose regime of the MRNA vaccine (They were around 50%, though the data ended when people got the second dose so cannot tell final /peak efficacy). The single dose mrna was tried in Phase 1 but they (Pfizer and Moderna) opted for the lower dosage two shot protocol.

 

[Animal_Kingdom_09]

What do you think will happen when Disney's CMs are vaccinated, and if studies show that people who are vaccinated are protected against both getting sick and transmitting the virus? I know it's speculative, but I'm wondering what people would consider reasonable under those circumstances. We're nowhere near that point now, but at some point I assume most of the people going to Disney will have been vaccinated. What would be the rationale at that point for keeping masks? Maybe it's just too soon for a reliable answer.

Two milestones have to happen. First, the vaccine has to be available to CM's. The full on mask rules are the result of Disney's agreement with its union to require masks to be mandatory. Second, Orange county will have to change their mask mandate. While mask mandates are voluntary with respect to individuals, that is not true for businesses and they can be fined, at least in Florida.

 

[GoofGoof]

The results of their two dose study efficacy will be interesting.

The efficacy of their single dose is greater than the efficacy of just the first dose of a two dose regime of the MRNA vaccine (They were around 50%, though the data ended when people got the second dose so cannot tell final /peak efficacy). The single dose mrna was tried in Phase 1 but they (Pfizer and Moderna) opted for the lower dosage two shot protocol.

I don’t tknow when that result comes out but I imagine if it’s much better they add a booster to JnJ too. I kinda think with the variants out there everyone will be getting a booster this fall anyway.

 

[SamusAranX]

Theres a group of people who are eager and will gladly take any shot, andJ&J proves itself to be a good shot.

But theres also already much resistance, its going to be hard to convince people who won't even take a shot with 95% efficacy, to take the J&J one. A common argument is "Why would I take a shot that's only 95% efficient in MAYBE preventing serious cases."

Then these holdouts should not be allowed into Disney, concerts, cruises and so on. And they can't cry "my rights" as these are private businesses and allowed to refuse service for public health

 

[dreday3]

Theres a group of people who are eager and will gladly take any shot, andJ&J proves itself to be a good shot.

But theres also already much resistance, its going to be hard to convince people who won't even take a shot with 95% efficacy, to take the J&J one. A common argument is "Why would I take a shot that's only 95% efficient in MAYBE preventing serious cases."

First, I think that group of people that are resisting is growing smaller and smaller.

Second, if you have a vaccine readily available to you and still choose not to get it, then take it falls on you to take extra precautions. The world isn't going to stay on hold for hold-outs.

 

[Sirwalterraleigh]

Yes. It's still good enough to get the job done of reducing hospitalizations and severity, so it should be used where needed most. All the while production ramps up on the "good" ones, so they can become more widely available and perhaps places can work on the storage issues in the meantime.

joe’s army tipped their hand a little the other day...

“Merck...meet moderna”

Can’t say J&J might not do some “side production”
As well

 

[Animal_Kingdom_09]

I don’t tknow when that result comes out but I imagine if it’s much better they add a booster to JnJ too. I kinda think with the variants out there everyone will be getting a booster this fall anyway.

Based on their phase 2 trial, a second shot at day 57 (no idea why the picked 57 days) boosted the efficacy above 90%, f I remember correctly.

 

[Sirwalterraleigh]

Based on their phase 2 trial, a second shot at day 57 (no idea why the picked 57 days) boosted the efficacy above 90%, f I remember correctly.

Yeah...they immediately went second shot when they saw the data

What sucks is that will reduce production...it was all based on 1 shot.

Still better than nothing...but less coverage