Coronavirus and Walt Disney World general discussion

Status
Not open for further replies.

MisterPenguin

President of Animal Kingdom
Premium Member
Update to the vaccine timeline outline in red...

Reading about the status of various vaccines have left me confused as to which vaccines are which and where they are in development and who's saying what about how far along they are. So, I made an outline...


Monderna/NIH

Type: mRNA (requires ultra-cold storage, -20C, and 2 doses)​
Warp Speed: $2.5B, for 100M doses​
Phase 3: Started Jul 27, 30K people, enrollment completes in September​
Earliest according to CDC: “Vaccine B” – local health departments, prepare for Oct (just in case, if all goes very well). Late Oct or Nov. 1M doses by Oct, 10M by Nov, 15M by Dec.​
Earliest according to manufacturer: by the end of 2020.



Biontech/Pfizer/Fosun

Type: mRNA (requires ultra-cold storage, -70C, and 2 doses)​
Phase 3: Started Jul 27, 30K people​
Warp Speed: $1.9B for 100M doses (by Dec?)​
Earliest according to CDC: “Vaccine A” – local health departments, prepare for Oct (just in case, if all goes very well). Late Oct or Nov. 2M doses by end of Oct, 10-20M doses by Nov, 20-30M dosed by Dec.​
Earliest according to manufacturer: Regulatory review in Oct. which could theoretically lead to early end of Phase 3.



AstraZeneca/Oxford

Type: altered chimp adenovirus​
Warp Speed: $1.2B​
Phase 3: in progress, recently started​
Earliest according to CDC: Doses can be delivered by Oct.​
Earliest according to manufacturer: Doses available by the end of 2020.​





Phase 3:

Final phase of trials. A large number of people are given either the vaccine or placebo, double blind​
Wait to see if there are negative reactions to the vaccine. If there are, vaccine is scrubbed.​
Wait to see how much more the vaccinated group is protected compared to the placebo. To be effective, people should be at least 50% more protected.​
If early results show extraordinarily good results, then this Phase can end early, because it would be unethical to leave those who received the placebo to be unprotected by an effective vaccine – this is what leads to an “October vaccine,” which, is only a result of extraordinarily good results.​
An independent review board evaluates the effectiveness. The FDA will not approve (or, is not supposed to approve) a vaccine without the board's go-ahead.​
In addition to governmental approval (or "fast-tracking"), the manufacturers themselves can decide not to release the vaccine until what they consider are appropriate evaluations are made. And, in fact, have pledged to "follow the science" and not release the vaccine until large trials and the science show that it is both safe and effective.



In short, as Dr. Fauci has said, an October vaccine is not impossible, just very unlikely.
 

MisterPenguin

President of Animal Kingdom
Premium Member
1599568136861.png



1599568118229.png
 

GoofGoof

Premium Member
Update to the vaccine timeline outline in red...

Reading about the status of various vaccines have left me confused as to which vaccines are which and where they are in development and who's saying what about how far along they are. So, I made an outline...


Monderna/NIH

Type: mRNA (requires ultra-cold storage, -20C, and 2 doses)​
Warp Speed: $2.5B, for 100M doses​
Phase 3: Started Jul 27, 30K people, enrollment completes in September​
Earliest according to CDC: “Vaccine B” – local health departments, prepare for Oct (just in case, if all goes very well). Late Oct or Nov. 1M doses by Oct, 10M by Nov, 15M by Dec.​
Earliest according to manufacturer: by the end of 2020.



Biontech/Pfizer/Fosun

Type: mRNA (requires ultra-cold storage, -70C, and 2 doses)​
Phase 3: Started Jul 27, 30K people​
Warp Speed: $1.9B for 100M doses (by Dec?)​
Earliest according to CDC: “Vaccine A” – local health departments, prepare for Oct (just in case, if all goes very well). Late Oct or Nov. 2M doses by end of Oct, 10-20M doses by Nov, 20-30M dosed by Dec.​
Earliest according to manufacturer: Regulatory review in Oct. which could theoretically lead to early end of Phase 3.



AstraZeneca/Oxford

Type: altered chimp adenovirus​
Warp Speed: $1.2B​
Phase 3: in progress, recently started​
Earliest according to CDC: Doses can be delivered by Oct.​
Earliest according to manufacturer: Doses available by the end of 2020.​





Phase 3:

Final phase of trials. A large number of people are given either the vaccine or placebo, double blind​
Wait to see if there are negative reactions to the vaccine. If there are, vaccine is scrubbed.​
Wait to see how much more the vaccinated group is protected compared to the placebo. To be effective, people should be at least 50% more protected.​
If early results show extraordinarily good results, then this Phase can end early, because it would be unethical to leave those who received the placebo to be unprotected by an effective vaccine – this is what leads to an “October vaccine,” which, is only a result of extraordinarily good results.​
An independent review board evaluates the effectiveness. The FDA will not approve (or, is not supposed to approve) a vaccine without the board's go-ahead.​
In addition to governmental approval (or "fast-tracking"), the manufacturers themselves can decide not to release the vaccine until what they consider are appropriate evaluations are made. And, in fact, have pledged to "follow the science" and not release the vaccine until large trials and the science show that it is both safe and effective.



In short, as Dr. Fauci has said, an October vaccine is not impossible, just very unlikely.
On a side note I saw an interview with someone from the Oxford Group and they said they may release some prelim results from their phase 3 trial in a few weeks. Just basically an unofficial update on whether it’s working or not. They started a phase 3 trial earlier outside of the US which is ahead of their US trial so I’m assuming it’s results from that but if it works in the U.K. or Brazil or India it should work here too.
 

DisneyDebRob

Well-Known Member
Update to the vaccine timeline outline in red...

Reading about the status of various vaccines have left me confused as to which vaccines are which and where they are in development and who's saying what about how far along they are. So, I made an outline...


Monderna/NIH

Type: mRNA (requires ultra-cold storage, -20C, and 2 doses)​
Warp Speed: $2.5B, for 100M doses​
Phase 3: Started Jul 27, 30K people, enrollment completes in September​
Earliest according to CDC: “Vaccine B” – local health departments, prepare for Oct (just in case, if all goes very well). Late Oct or Nov. 1M doses by Oct, 10M by Nov, 15M by Dec.​
Earliest according to manufacturer: by the end of 2020.



Biontech/Pfizer/Fosun

Type: mRNA (requires ultra-cold storage, -70C, and 2 doses)​
Phase 3: Started Jul 27, 30K people​
Warp Speed: $1.9B for 100M doses (by Dec?)​
Earliest according to CDC: “Vaccine A” – local health departments, prepare for Oct (just in case, if all goes very well). Late Oct or Nov. 2M doses by end of Oct, 10-20M doses by Nov, 20-30M dosed by Dec.​
Earliest according to manufacturer: Regulatory review in Oct. which could theoretically lead to early end of Phase 3.



AstraZeneca/Oxford

Type: altered chimp adenovirus​
Warp Speed: $1.2B​
Phase 3: in progress, recently started​
Earliest according to CDC: Doses can be delivered by Oct.​
Earliest according to manufacturer: Doses available by the end of 2020.​





Phase 3:

Final phase of trials. A large number of people are given either the vaccine or placebo, double blind​
Wait to see if there are negative reactions to the vaccine. If there are, vaccine is scrubbed.​
Wait to see how much more the vaccinated group is protected compared to the placebo. To be effective, people should be at least 50% more protected.​
If early results show extraordinarily good results, then this Phase can end early, because it would be unethical to leave those who received the placebo to be unprotected by an effective vaccine – this is what leads to an “October vaccine,” which, is only a result of extraordinarily good results.​
An independent review board evaluates the effectiveness. The FDA will not approve (or, is not supposed to approve) a vaccine without the board's go-ahead.​
In addition to governmental approval (or "fast-tracking"), the manufacturers themselves can decide not to release the vaccine until what they consider are appropriate evaluations are made. And, in fact, have pledged to "follow the science" and not release the vaccine until large trials and the science show that it is both safe and effective.



In short, as Dr. Fauci has said, an October vaccine is not impossible, just very unlikely.
On a side note I saw an interview with someone from the Oxford Group and they said they may release some prelim results from their phase 3 trial in a few weeks. Just basically an unofficial update on whether it’s working or not. They started a phase 3 trial earlier outside of the US which is ahead of their US trial so I’m assuming it’s results from that but if it works in the U.K. or Brazil or India it should work here too.
Weird. I just read a report a few days ago where the AstraZeneca trial would probably be able to have the findings by thanksgiving. With, if everything goes well, roll out in December or January. Have they changed things? I’m trying to find the article again but they said that would be the earliest because they were not shortening the Phase 3 trials. Anything sooner would not be ethical.
Edit- Just realized you weren’t talking about the US trial
 

GoofGoof

Premium Member
Weird. I just read a report a few days ago where the AstraZeneca trial would probably be able to have the findings by thanksgiving. With, if everything goes well, roll out in December or January. Have they changed things? I’m trying to find the article again but they said that would be the earliest because they were not shortening the Phase 3 trials. Anything sooner would not be ethical.
Edit- Just realized you weren’t talking about the US trial
Yes, not US. They didn’t say which trial but I believe they are running trials in the U.K., Brazil and South Africa as well as the US one. The US one is still enrolling participants and they need to get 2 injections 30 days apart so it won’t be done until November here at the earliest. None of the trials are complete but the guy in the interview said they may release a statement on preliminary results in the next few weeks. I doubt they would release bad news so probably a good sign.
 

Miss Bella

Well-Known Member
Sure. Seems like most people might use different criteria when deciding how/when/whether to visit an essential business vs. a non-essential vacation destination, right?
I wouldn't say most people, but yes obviously there is a percentage of people who do.
 

_caleb

Well-Known Member
There are thousands of people working at large corporations that have or have had Covid. It may have made news at the beginning of this outbreak, but it certainly isn't news now.
I wouldn't say most people, but yes obviously there is a percentage of people who do.
So then this would qualify as news for that percentage of people then? Why would you be quick to dismiss it?
 

Miss Bella

Well-Known Member
So then this would qualify as news for that percentage of people then? Why would you be quick to dismiss it?
If you live in a state that's a had a significant outbreak like mine or Florida I'm not sure a breakout out at any one business is newsworthy. When 10- 15 thousand people are testing positive every day would anyone in Florida be shocked that WDW employees have or have had COVID?
 

GimpYancIent

Well-Known Member
If you live in a state that's a had a significant outbreak like mine or Florida I'm not sure a breakout out at any one business is newsworthy. When 10- 15 thousand people are testing positive every day would anyone in Florida be shocked that WDW employees have or have had COVID?
A good shot of 100 proof spirits in the morning puts a different look on the day. Hey! alcohol kills 100% of viruses.
 

_caleb

Well-Known Member
If you live in a state that's a had a significant outbreak like mine or Florida I'm not sure a breakout out at any one business is newsworthy. When 10- 15 thousand people are testing positive every day would anyone in Florida be shocked that WDW employees have or have had COVID?
Something doesn't have to be "shocking" in order for it to be newsworthy. I would argue that it's precisely because of those 10-15 thousand positive tests per day that info about the impact to Disney parks might be news–especially for out-of state folks weighing an expensive, non-essential trip to the parks.
 

Miss Bella

Well-Known Member
Something doesn't have to be "shocking" in order for it to be newsworthy. I would argue that it's precisely because of those 10-15 thousand positive tests per day that info about the impact to Disney parks might be news–especially for out-of state folks weighing an expensive, non-essential trip to the parks.
Like I said in my previous post I got numerous emails from Disney warning me of the risks of being exposed to COVID. I got numerous push notifications on my App.
Do people really think cast members have some kind of magical immunity and the only exposer risk is from other guests? The papers are full of stories that I wouldn't consider newsworthy and I have no problem with them running stories about cast members with COVID. I just have a hard time believing that anyone would be surprised by this.
 

_caleb

Well-Known Member
Like I said in my previous post I got numerous emails from Disney warning me of the risks of being exposed to COVID. I got numerous push notifications on my App.
Do people really think cast members have some kind of magical immunity and the only exposer risk is from other guests? The papers are full of stories that I wouldn't consider newsworthy and I have no problem with them running stories about cast members with COVID. I just have a hard time believing that anyone would be surprised by this.
Those email messages are from Disney. They are warning you of the risk, but they're not notifying you whether they are calling COVID-positive CMs to work (as is being alleged by DL CMs in The Daily Beast article).

Nobody thinks Disney CMs are immune to the risks of exposure. They may not realize that CMs are concerned that Disney isn't uniformly enforcing its own policies for CMs. No one is saying you (or anyone) should be "shocked" or "surprised" by this. It is simply more information than many of us have, so it's news.
 
Status
Not open for further replies.

Register on WDWMAGIC. This sidebar will go away, and you'll see fewer ads.

Back
Top Bottom