Pfizer Vaccine News

lazyboy97o

Well-Known Member
Pfizer has characterized their results as preliminary. Mostly, I've just tied to explain why I agree that these first results are still preliminary. There's still much to learn. If that makes me a bad guy, okay.
You are not just arguing cautious optimism about this preliminary data. You are calling into question the entire approval process, repeatedly claiming without evidence that vaccines can and do cause side effects months to years after administration.
I dunno, didn't the whole opioid epidemic make you at all concerned or cautious? It feels like we sometimes have a very short collective memory.
The difference has been explained. What vaccine is addictive and taken on a recurring basis?
 

Calmdownnow

Well-Known Member
The EU is part of Warp Speed? Pfizer has not received a dime yet, as I said. They only get paid under the Warp Speed program when they deliver the vaccine.
I think the point of the post was that companies did not need Trump money to generate speedy vaccine development because other nations/multinational groups put money into initiatives, sometimes many months before the bizarrely-named "warp speed", "Star Trek", effort began. The EU had an advanced purchase initiative with multiple possible vaccine producers in June. The US was quite late to the table in comparison.
Edit: just a jocular side note, but does anyone else feel, on the Star Trek warp speed analogy, that Jared K looks like a CGI mix-up of footage of Data and Spock
 

MickeyLuv'r

Well-Known Member
Yes, seriously. You keep claiming side effects months to years after administration is something that happens so you should be able to provide some examples.
No, you keep saying that. I've refuted it multiple times.

This is what Pfizer says they are doing:
Pfizer and BioNTech are continuing to accumulate safety data and currently estimate that a median of two months of safety data following the second (and final) dose of the vaccine candidate.... Additionally, participants will continue to be monitored for long-term protection and safety for an additional two years after their second dose. - source: Pfizer

Pfizer plans to collect more data.
 

JIMINYCR

Well-Known Member
What do you think the trials were about. You don't have to take the vaccine if you don't want to but plenty of people will trust the trials. Exactly what would make you believe the effectiveness of the vaccine?
I am going to take it when available. I do have hope that it is going to produce 90% or better effectiveness. I do trust the announced positive results of the trials. But I am also cognizant in the reality that in the past there have been vaccines that have had problems when rolled out en mass to the public. Just because something has gone through trials does not ensure that it has no issues that were not discovered during trials. I dont care how many of the 20000 test cases ( thats 40000 minus the placebos) were fine. Theres no infallibility to anything. My initial post stands. We will not know how it will be affecting large portions of people until its tried. You, the detractors on here, nobody can ensure what results will be.
During a trial most often there are specific guidelines for those who are chosen to participate in the trial. When a medication is given to the general public after approval, all of the people receiving it have varying health issues, health histories and such that may have negated their ability to participate in a trial. Therefore results are potentially going to be different on the population receiving it.
As an example, my DW has MS. There was an IV med that had gone through trials. And approved. Once it went out to people, there were deaths that began ocurring that had not been shown in the trials. They pulled it from the market, did more research, discovered it could cause a brain infection known as PML. They discovered which people could be at higher risk when on the drug, they reintroduced it with stricter guidelines and cautions in place so people would know what could happen. The drug was Tysabri, put out by Biogen.
Again in this case, stringent trials among a large number of test subjects for this, did not reveal what ultimately showed up after release.
 

GoofGoof

Premium Member
No, you keep saying that. I've refuted it multiple times.

This is what Pfizer says they are doing:
Pfizer and BioNTech are continuing to accumulate safety data and currently estimate that a median of two months of safety data following the second (and final) dose of the vaccine candidate.... Additionally, participants will continue to be monitored for long-term protection and safety for an additional two years after their second dose. - source: Pfizer

Pfizer plans to collect more data.
They have to collect more data. The 2 months is for Emergency Use Authorization only. They still need more safety and efficacy data before they get full FDA approval. They have committed to watching trial participants for up to 2 years. This is all pretty standard. It doesn‘t mean they expect to find anything wrong or that it’s likely. In reality it’s far more likely that the vaccine gets recalled if it shows the efficacy wasn’t as good as we thought. After a year or 2 They can look back and actually see how many people got Covid anyway. It’s entirely possible that one or all of this first wave of vaccines gets their approval pulled if a more effective vaccine or one with less side effects replaces it. The side effects could be mild to moderate. For example if these vaccines cause fever and flu like symptoms in 50% of the participants that’s not a reason to not authorize them during a pandemic, but if another of the 40+ vaccines in development comes out this time next year and is just as effective but has a way lower level of side effects they may very well recommend a switch to it.
 
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GoofGoof

Premium Member
I think the point of the post was that companies did not need Trump money to generate speedy vaccine development because other nations/multinational groups put money into initiatives, sometimes many months before the bizarrely-named "warp speed", "Star Trek", effort began. The EU had an advanced purchase initiative with multiple possible vaccine producers in June. The US was quite late to the table in comparison.
Edit: just a jocular side note, but does anyone else feel, on the Star Trek warp speed analogy, that Jared K looks like a CGI mix-up of footage of Data and Spock
I don’t care who gets credit. Trump money, Obama Care it’s all a little too ego driven for me. The fact of the matter is the scientists working around the world did this at great personal sacrifice too. These people have been working 7 days a week around the clock to get where we are and there’s still a lot more to go. I think if anyone deserves the credit it’s them, but I understand politics is politics and politicians are going to do what they do. I’m glad that most of the nations of the world joined together and dedicated lots of resources on this. I think when we look back on this pandemic and the race for a vaccine it will likely go down as one of the greatest scientific achievements in history.
 

correcaminos

Well-Known Member
I am going to take it when available. I do have hope that it is going to produce 90% or better effectiveness. I do trust the announced positive results of the trials. But I am also cognizant in the reality that in the past there have been vaccines that have had problems when rolled out en mass to the public. Just because something has gone through trials does not ensure that it has no issues that were not discovered during trials. I dont care how many of the 20000 test cases ( thats 40000 minus the placebos) were fine. Theres no infallibility to anything. My initial post stands. We will not know how it will be affecting large portions of people until its tried. You, the detractors on here, nobody can ensure what results will be.
During a trial most often there are specific guidelines for those who are chosen to participate in the trial. When a medication is given to the general public after approval, all of the people receiving it have varying health issues, health histories and such that may have negated their ability to participate in a trial. Therefore results are potentially going to be different on the population receiving it.
As an example, my DW has MS. There was an IV med that had gone through trials. And approved. Once it went out to people, there were deaths that began ocurring that had not been shown in the trials. They pulled it from the market, did more research, discovered it could cause a brain infection known as PML. They discovered which people could be at higher risk when on the drug, they reintroduced it with stricter guidelines and cautions in place so people would know what could happen. The drug was Tysabri, put out by Biogen.
Again in this case, stringent trials among a large number of test subjects for this, did not reveal what ultimately showed up after release.
Just an FYI for this trial they were taking and expanded to those who are immune compromised in some ways.
 

MickeyLuv'r

Well-Known Member
Opioids are not vaccines. I only mentioned them as an example of a time the drug companies were sued, because it is among the most well known times they have been sued. There are a number of other times they have been sued, but those have largely been eclipsed by other news stories over the last few years.

I am merely trying to explain my opinion, and share reputable sources to explain my thinking. I have some reservations yet. I thought that's why we have a forum.

Sigh.
 
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DisneyTransport

Active Member
I don’t care who gets credit. Trump money, Obama Care it’s all a little too ego driven for me. The fact of the matter is the scientists working around the world did this at great personal sacrifice too. These people have been working 7 days a week around the clock to get where we are and there’s still a lot more to go. I think if anyone deserves the credit it’s them, but I understand politics is politics and politicians are going to do what they do. I’m glad that most of the nations of the world joined together and dedicated lots of resources on this. I think when we look back on this pandemic and the race for a vaccine it will likely go down as one of the greatest scientific achievements in history.
THIS. Scientists often get disregarded and ignored until they are needed. Its a shame. YOU GO RESEARCHERS! they’re the real MVPs, not politicians
 

MickeyLuv'r

Well-Known Member
They have to collect more data. The 2 months is for Emergency Use Authorization only. They still need more safety and efficacy data before they get full FDA approval. They have committed to watching trial participants for up to 2 years. This is all pretty standard. It doesn‘t mean they expect to find anything wrong or that it’s likely. In reality it’s far more likely that the vaccine gets recalled if it shows the efficacy wasn’t as good as we thought. After a year or 2 They can look back and actually see how many people got Covid anyway. It’s entirely possible that one or all of this first wave of vaccines gets their approval pulled if a more effective vaccine or one with less side effects replaces it. The side effects could be mild to moderate. For example if these vaccines cause fever and flu like symptoms in 50% of the participants that’s not a reason to not authorize them during a pandemic, but if another of the 40+ vaccines in development comes out this time next year and is just as effective but has a way lower level of side effects they may very well recommend a switch to it.
Yes, they have to collect more data. The vaccine has not yet been approved. That's largely what I said, but thank you for posting the longer explanation.

So far they have not reported any side effects. It looks good, but it is preliminary. The only place I differ with you is the compressed timing makes me personally a little unsure at this time. More data, more peer review...all of that will build trust over time - as long as results continue to look favorable.

If 40 vaccines are safe and effective, distributing them worldwide would likely be easier to achieve. Bonus if they are all slightly different, that would probably help in putting this pandemic down more effectively.
 

GoofGoof

Premium Member
Yes, they have to collect more data. The vaccine has not yet been approved. That's largely what I said, but thank you for posting the longer explanation.

So far they have not reported any side effects. It looks good, but it is preliminary. The only place I differ with you is the compressed timing makes me personally a little unsure at this time. More data, more peer review...all of that will build trust over time - as long as results continue to look favorable.

If 40 vaccines are safe and effective, distributing them worldwide would likely be easier to achieve. Bonus if they are all slightly different, that would probably help in putting this pandemic down more effectively.
I think the biggest advantage to a few of the vaccines that aren’t as far along is that they are single dose and don’t require the same level of cold storage. The JnJ vaccine which is probably only a month behind the front runners is one of them. There are many parts of the world where the power grid isn’t even stable so not easy to distribute a vaccine that requires deep freezing. The more the better.

The compressed timing is a risk, but for me I just look at the overall situation and think it’s probably worth it.
 

GoofGoof

Premium Member
Okay, one last link. This one explains much of what I was trying to say in a way that is easy to understand (and not from me!) I especially like how they explain what the 90% effectiveness rate means.

Good summary. I think the conclusion is important to highlight:

Are there any misunderstandings that you think need to be cleared up?​

Dowdy: The public should understand that in general, vaccines are held to a very high standard of safety, since they're given to people who are otherwise healthy. So although we can never rule out very rare side effects, we can rest assured that if this vaccine is approved by the FDA, it's safe enough for you to take.
 

KTK

Active Member
I will delay getting this vaccine for as long as possible. Too much political agenda surrounding this situation.
Pfizer, who is making one of the vaccines, took no money from the American government I suspect in order for their vaccine not to be "political." The more people who get the vaccine, the sooner we can get back to normal because what we are doing now is not working.
 

Goofyernmost

Well-Known Member
Man, if I had a way of locking my own thread, I would have done it days ago.
Not meaning to be snotty, but why? This is a discussion forum and it can't just always be things that you agree with. Or what I agree with actually. What is being said in most cases is really sincere and it is the other side. It may be the side that you agree with or the one that you don't, but thinking you did wrong by starting the thread is just silly.

In my opinion discussion boards become nothing more than preaching if only one side is allowed to speak. Just because someone says something really doesn't mean that everyone will just accept and believe things that are said. Yes, I have seen some pretty off the wall stuff on this particular thread, but mostly it just points out the general ignorance of the public. They don't do research but they are willing to pass along things that someone else told them. It's to much work to get the real answer from people that actually know.

As far as any discussion board, like this one, it's members are made up of people that know nothing and know it, people that know nothing but are quite sure that they know everything, people that are well read and still may have leaned in a particular direction, and people that really are somewhat informed. The key thing to remember is that those that really count, those that really do know what is going on and are actively working on the problem, hands on, are way to busy to be spending valuable time discussion what Mickey Mouse fans think about the worlds events.
 

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