If the Defenders make it in, it'll be a 5-10 second cameo. Like, Peter has an internship at the Daily Bugle and takes a picture of 4 street heroes fighting in NYC. I'm guessing that Infinity War will end with Thanos acquiring all 6 stones for the Gauntlet. Certain characters are definitely going to die depending on their relationship to the stones: Space Stone (Tessaract)- on Asgard. Mind Stone- literally keeping Vision alive (bye Vision, your death is going to absolutely wreck Wanda ) Reality Stone (the Aether)- with the Collector (bye Collector) Power Stone- with the Nova Corps... So say goodbye to Glenn Close and maybe John C. Reilly Time Stone- in Nepal? Maybe say goodbye to Wong, they're not killing off Stephen Strange Soul Stone- will probably end up with the Grandmaster by the end of Thor 3, though he could give it to the Collector If AMatW takes place during Infinity War, that might help a bit, though Feige has said he doesn't want the films to overlap anymore (outside of GOTG 2) Some characters (like maybe Nick Fury and Hawkeye) could be killed off for real, but some (maybe a Guardian or two) could be killed then brought back to life? Idk, depends on their film contracts, I suppose.