I think it could work really well with a post series storyline. SPOILERS for those who haven't finished the series:
Hurley in charge of the island now has made travel to and from it open to the public, your party goes into a pre-show room in the Temple, where Ben, former leader of the Others and now second in command to Hurley, gives you a little history of the island and what he and Hurley and trying to accomplish on it. Of course during his demonstration, something horribly goes wrong and the MiB appears once again on the island to cause some chaos. For whatever reason, you're charged with having to chase him down to try to stop him, you're possibly all new candidates to take Hurley's position in the future. You go from this pre-show room to the load area where you get on a dark ride/coaster and experience a trip around the island and through time so you actually get to experience some of the famous scenes from the show.