It's been a few years since I've driven to WDW, but...since I drove from the Dayton area...I have made that same trip.
We had two drivers and would leave around 9PM. We'd get through Atlanta and hit a rest area to sleep for a couple of hours, around 4AM. Usually, I would do that entire drive since I can't really sleep in a car. Then driver # 2 would take over and we'd drive an hour or so more and then stop for breakfast, a face splash and a little frisbe throwing...which always made us wake up! We would end up in Kissimee around 2pm??? where we would then check in to a motel for a shower and a long nap...After dinner, we'd hit the sack early and then check into our Disney resort first thing in the morning and hit the parks.
The drive there isn't horrible because of the anticipation. I loved driving at night although the Smokey Mountain fogs can sometimes be bad. The drive home is rougher since the trip has worn you out but we make lots of stops to stretch our legs, revive ourselves and try to enjoy the trip/scenery in the day light. We leave early in the morning and we always stop around Knoxville at a motel and that makes for a shorter drive home the next day. I'm usually so sad that my WDW vacation is over that I try to milk that ride home adding in some fun stops to fool myself into thinking I'm still on vacation. That old saying, it's the journey, not the destination, type of thing. :lol
Oh, also...we've added a few days ocean side for some complete R&R after a drive to WDW and the Disney part is over. We've also tacked on a couple days at Norris Lake in the Knoxville area. Nice stops to make after WDW.
Enjoy....