Coronavirus and Walt Disney World general discussion

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Vegas Disney Fan

Well-Known Member
Would it be nice to go back to the summer of 2019 and hang out in a packed bar, shoulder to shoulder drinking and cheering some event with everyone right on top of each other without a care in the world? Maybe, but that's probably just gone forever. It's the new forward.
That exact scenario has been back in every state for several months already.

Even in the most restrictive/cautious states life is 90% back to normal, stadiums are open, theaters are open, businesses are open, churches are open… we’ve come a long way from summer of 2020.

We tend to focus on the negative (masks, shortages, etc) but the reality is we’ve already plowed forward.
 

Heppenheimer

Well-Known Member
The FDA has issued an EUA for Pfizer's COVID antiviral pill -

"Today, the U.S. Food and Drug Administration issued an emergency use authorization (EUA) for Pfizer’s Paxlovid (nirmatrelvir tablets and ritonavir tablets, co-packaged for oral use) for the treatment of mild-to-moderate coronavirus disease (COVID-19) in adults and pediatric patients (12 years of age and older weighing at least 40 kilograms or about 88 pounds) with positive results of direct SARS-CoV-2 testing, and who are at high risk for progression to severe COVID-19, including hospitalization or death. Paxlovid is available by prescription only and should be initiated as soon as possible after diagnosis of COVID-19 and within five days of symptom onset.

“Today’s authorization introduces the first treatment for COVID-19 that is in the form of a pill that is taken orally — a major step forward in the fight against this global pandemic,” said Patrizia Cavazzoni, M.D., director of the FDA’s Center for Drug Evaluation and Research. “This authorization provides a new tool to combat COVID-19 at a crucial time in the pandemic as new variants emerge and promises to make antiviral treatment more accessible to patients who are at high risk for progression to severe COVID-19.”

Paxlovid is not authorized for the pre-exposure or post-exposure prevention of COVID-19 or for initiation of treatment in those requiring hospitalization due to severe or critical COVID-19. Paxlovid is not a substitute for vaccination in individuals for whom COVID-19 vaccination and a booster dose are recommended. The FDA has approved one vaccine and authorized others to prevent COVID-19 and serious clinical outcomes associated with a COVID-19 infection, including hospitalization and death. The FDA urges the public to get vaccinated and receive a booster if eligible. Learn more about FDA-approved or -authorized COVID-19 vaccines.

Paxlovid consists of nirmatrelvir, which inhibits a SARS-CoV-2 protein to stop the virus from replicating, and ritonavir, which slows down nirmatrelvir’s breakdown to help it remain in the body for a longer period at higher concentrations. Paxlovid is administered as three tablets (two tablets of nirmatrelvir and one tablet of ritonavir) taken together orally twice daily for five days, for a total of 30 tablets. Paxlovid is not authorized for use for longer than five consecutive days."

More at the link below -

This is good news and a useful tool to have in our arsenal, but this drug will not get us out of the pandemic. At best, paxlovid will relieve some of the pressure on hospitals. From what I read in the supporting literature, it looks like there was about a 78% reduction in hospitalizations in the treatment versus the placebo arm, and zero all-cause mortality deaths vs 12 in the placebo group during the approximately month long observation period. Interesting that 47% of the trial participants were "serologically negative", meaning either they were unvaccinated, without prior infection, or their existing immunity from either source faded completely (less likely, though).

The medication is only authorized for those considered "high risk of hospitalization", but I noticed they included anyone with a BMI above 25 in that list, so effectively most adults living in the western world will probably meet the eligibility criteria. I'm pretty sure the criteria is a BMI above 30 for the monoclonal antibody, so more people will likely qualify for this oral treatment than for the infusion.

Like tamiflu, this medication needs to be given as soon as possible after symptoms develop. With the availability of at-home tests for COVID, this should make it much easier to hit the eligible population in the proper time window.

Now, the all-important caveats. Unlike the very rare incidence of severe side effects in the vaccines, protease inhibitors tend to have some rather significant toxicities. This might not be a huge issue, because we usually see these side effects with chronic use of the medications in HIV patients, and the prescribed course of paxlovid is relatively short. We'll probably only get a better handle of this as the medication becomes more widely administrated in the general population.

The other surprising caveats were some of the drug interactions that will contraindicate paxlovid use. Some of these drugs are fairly common, such as alfuzosin, amiodarone, flecanide, carbamazepine, phenytoin, lovastatin, simvastatin, salmeterol, and even sildenafil (aka, viagra). Some of the contraindicated medications can probably be stopped temporarily, but someone taking amiodarone and flecanide for a heart arrhythmia, carbamazepine or phenytoin for seizures, or sildenafil for pulmonary hypertension can't just stop these medications without potentially severe consequences. So, some of the people who are sickest and most vulnerable at baseline may not be able to take paxlovid.
 
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mmascari

Well-Known Member
Walmart delivery just arrived with what feels like the last at home tests anywhere in the area. Scooped them up from the porch before something happened. Now, the website shows nothing for delivery and nothing in any nearby store. Three boxes and we're going to use two prior to visiting some family. The instinct to hoard and regret of not ordering six boxes is strong.

This should come in handy, they are slightly harder to use than a pregnancy test.


Here's hoping for solid red. 🤣
 

dreday3

Well-Known Member
Walmart delivery just arrived with what feels like the last at home tests anywhere in the area. Scooped them up from the porch before something happened. Now, the website shows nothing for delivery and nothing in any nearby store. Three boxes and we're going to use two prior to visiting some family. The instinct to hoard and regret of not ordering six boxes is strong.

This should come in handy, they are slightly harder to use than a pregnancy test.


Here's hoping for solid red. 🤣

I'm behind the times.
All I'm getting delivered today is perfume and a pair of shoes! :D

We have no tests in stock around us, but honesty we aren't looking to buy any. We are just seeing immediate family on Friday (that we see all the time), all of which are vaccinated and boosted. If I felt sick I would go get a test, but I don't.
 

Incomudro

Well-Known Member
I wonder sometimes that society is the pandemic, COVID just exposed it.
Well, a good portion of society, particularly US society is composed of people who are unhealthy, physical messes, mostly due to their lifestyle habits.
Covid exposed that.
Mitigation measures have actually increased many of the components that make people vulnerable to covid.
 

Ayla

Well-Known Member
That exact scenario has been back in every state for several months already.

Even in the most restrictive/cautious states life is 90% back to normal, stadiums are open, theaters are open, businesses are open, churches are open… we’ve come a long way from summer of 2020.

We tend to focus on the negative (masks, shortages, etc) but the reality is we’ve already plowed forward.
In some places, we are starting to see a replay of March 2020. Churches are canceling in-person Christmas services, Broadway is closing shows, businesses are having to close because they don't have enough healthy staff, pro sports are being affected by players being out, etc.
 

Ayla

Well-Known Member
This is good news and a useful tool to have in our arsenal, but this drug will not get us out of the pandemic. At best, paxlovid will relieve some of the pressure on hospitals. From what I read in the supporting literature, it looks like there was about a 78% reduction in hospitalizations in the treatment versus the placebo arm, and zero all-cause mortality deaths vs 12 in the placebo group during the approximately month long observation period. Interesting that 47% of the trial participants were "serologically negative", meaning either they were unvaccinated, without prior infection, or their existing immunity from either source faded completely (less likely, though).

The medication is only authorized for those considered "high risk of hospitalization", but I noticed they included anyone with a BMI above 25 in that list, so effectively most adults living in the western world will probably meet the eligibility criteria. I'm pretty sure the criteria is a BMI above 30 for the monoclonal antibody, so more people will likely qualify for this oral treatment than for the infusion.

Like tamiflu, this medication needs to be given as soon as possible after symptoms develop. With the availability of at-home tests for COVID, this should make it much easier to hit the eligible population in the proper time window.

Now, the all-important caveats. Unlike the very rare incidence of severe side effects in the vaccines, protease inhibitors tend to have some rather significant toxicities. This might not be a huge issue, because we usually see these side effects with chronic use of the medications in HIV patients, and the prescribed course of paxlovid is relatively short. We'll probably only get a better handle of this as the medication becomes more widely administrated in the general population.

The other surprising caveats were some of the drug interactions that will contraindicate paxlovid use. Some of these drugs are fairly common, such as alfuzosin, amiodarone, flecanide, carbamazepine, phenytoin, lovastatin, simvastatin, salmeterol, and even sildenafil (aka, viagra). Some of the contraindicated medications can probably be stopped temporarily, but someone taking amiodarone and flecanide for a heart arrhythmia, carbamazepine or phenytoin for seizures, or sildenafil for pulmonary hypertension can't just stop these medications without potentially severe consequences. So, some of the people who are sickest and most vulnerable at baseline may not be able to take paxlovid.
Thank you for breaking things down and explaining them in a way us non-doctors are able to easily understand. It is much appreciated. :)
 

mf1972

Well-Known Member
i’ve had 2 nurses i work with (different shifts) who have both tested positive. they were vaccinated but i don’t know if they were boosted. 1 of them is 3-4 months pregnant but i hear she’s doing ok. i’ve had 2 other coworkers rail against the mandate when it was announced & vowed to get an exemption. 1 came around & got vaccinated, the other got the exemption.
we’ve had all sorts of covid patients come through my dept. adults, kids, babies, even pregnant women. some cases aren’t that bad, but the bad ones are another story. covid isn’t going anywhere anytime soon. i just hope people will come around & do the right thing. have a safe & merry christmas everyone.
 

Epcotfan21

Well-Known Member
Has there been any whisperings of bans on international travel?
Not that I’m aware of. I just think most individuals won’t want to come to a place that’s going to have 30k+ cases in the state each day. And that’s only the people that actually will go get tested at a site. The real number will be closer to 50k+ cases each day for the next two months.
 

Vegas Disney Fan

Well-Known Member
i’ve had 2 nurses i work with (different shifts) who have both tested positive. they were vaccinated but i don’t know if they were boosted. 1 of them is 3-4 months pregnant but i hear she’s doing ok. i’ve had 2 other coworkers rail against the mandate when it was announced & vowed to get an exemption. 1 came around & got vaccinated, the other got the exemption.
we’ve had all sorts of covid patients come through my dept. adults, kids, babies, even pregnant women. some cases aren’t that bad, but the bad ones are another story. covid isn’t going anywhere anytime soon. i just hope people will come around & do the right thing. have a safe & merry christmas everyone.
I can’t imagine working in a hospital and not being vaccinated. I was very hesitant to get the vaccine until the day they announced we were going back to work, the thought of being around hundreds of people a day was enough to convince me.

The thought of health care professionals being unvaccinated around hundreds of Covid positive people everyday is mind boggling.
 

Jim L

New Member
I acknowledge that it isn't *in theory* and some, like you, will say 'both.'

But right now, in reality, only one of them is practically "on the table" as a tool (at least among leaders that care about the pandemic and science).

But that shouldn't be. If the political calculus of leaders who should be following the science is not to get constituents angry, then they should chose Strategy B, a vaccination mandate. If everyone was vaccinated and boosted then you could avoid lockdowns and stop stressing about the 20% who won't wear masks or wear them properly, because, everyone's vaccinated.
That's not true though. With so many countries talking about closing it's not even a little off the table and under this administration it would actually be enforced. Also until mandatory proof of vaccinations must to go anywhere is a must
 
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