Coronavirus and Walt Disney World general discussion

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ArmoredRodent

Well-Known Member
so 50% is the same as the Pfizer regular?
It's more complicated than that. Moderna at 100% is more effective than at 50%, but 50% is really, really good, and saves a ton of vaccine and packaging. Plus, one of Moderna's advantages has always been that it doesn't need the advanced refrigeration that Pfizer does, so was much better for places without those super-fridges, like rural areas; the 50% dose also lets them send out the booster in smaller packages for smaller areas.
 

GoofGoof

Premium Member
"to determine in the coming weeks whether to recommend boosters only for recipients of the Pfizer-BioNTech vaccine — and possibly just some of them to start."

So then Moderna is not a problem right now?
Of course it’s not….it’s the far superior product in every way. Here’s the new t-shirt I ordered today;)
863501C0-E212-4A5A-917B-63821888DE63.jpeg
 

Dreaming of Disney World

Well-Known Member
Moderna is not a problem; their data is still very good. Two days ago, the company applied to the FDA for approval for a booster shot at 50% of the original dose, to be administered six months after the last original jab. NPR reported the company said: "Antibodies had waned six months after vaccination, the company said, but the third shot boosted antibodies to an even higher point than was seen after the initial shots, even though the booster was just half the original dose."
I hope that gets approved soon, because according to this new research I'm due for my second dose in October.
 

DisneyFan32

Well-Known Member
In the Parks
Yes

I'm scared about this Winter now.:(:( @GoofGoof
 

mmascari

Well-Known Member
Team J&J!

1 dose and we were done.
Gets better over time (at least at first)
It’s never in the news about waning protection.
Even if we need another jab after 6-8 months, that’s still only 2. 😎

We’re a 3 brand vaccine household. Last of the initial doses next week.
 

sndral

Well-Known Member
There is definitely something wrong with the CDC numbers for PA. The 1 dose vs fully vaccinated is way too wide. PA has 69.6% of total population and 82.6% of adults with 1 dose but 55.4% of total population and 66.1% of adults done. There’s no way 16% of adults skipped shot 2 or got shot 1 in the last 4 weeks. I believe there is an issue with some second shots being counted as new first shots that hasn’t been corrected yet. I know that happened in my county and they corrected locally. My guess is the true number is closer to the ballpark of north of 60% of total population and 70% of adults done which is around where NY and NJ sit and PA has been tracking similar to those states.
How do the J&J one and done folks get counted? My niece & her hubby live in PA and J&J was the first shot available to them, so that’s what they got.
Rest of the family got Pfizer except me - I ended up w/ Moderna, I wasn’t thrilled @ the time w/ the extra week of waiting between doses (my county took forever to offer vaxes to various groups - like months behind the rest of the state.) I’m hoping the roll out of booster shots won’t be a repeat of the cluster we saw last winter/spring.
 
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GoofGoof

Premium Member
I’d like to see a Pfizer/Moderna “house divided” flag. Kinda like the collegiate rivalry ones. How many couples here would need one apart from my wife and I?
My wife and I both got Moderna but the kids will both have Pfizer once they approve it for 11 year olds.

Team J&J!

1 dose and we were done.
Gets better over time (at least at first)
It’s never in the news about waning protection.
Even if we need another jab after 6-8 months, that’s still only 2. 😎

We’re a 3 brand vaccine household. Last of the initial doses next week.
I was talking to 2 college friends last night and one works for Pfizer and the other JnJ. I was encouraging them to buy the Moderna shirt and wear it to work just to see how people reacted 😎. The guy who works for JnJ was talking about how big a mess that plant in Baltimore turned out to be. We forget the details from back then, but JnJ had a few stumbles out of the gate that if they were avoided could have put them closer to even with the other 2 for total people vaccinated.
 

Polkadotdress

Well-Known Member
Sorry I'm confused, was she told she got the actual vaccine? That's what it would mean to be unblinded as part of a double-blind study.

Problem with not being unblinded is even if you suspect you have no proof. I know it sucks but it's something we risked joining the trials. I'm really sorry their studies seem to be more and more delayed on applying for approval here.
I guess I’m confused about what “unblinded” means, as I thought it denotes finding out when you got the vaccine? The study she was in ensures that everyone got the vaccine, since there were several rounds of shots.
 

sullyinMT

Well-Known Member
My wife and I both got Moderna but the kids will both have Pfizer once they approve it for 11 year olds.


I was talking to 2 college friends last night and one works for Pfizer and the other JnJ. I was encouraging them to buy the Moderna shirt and wear it to work just to see how people reacted 😎. The guy who works for JnJ was talking about how big a mess that plant in Baltimore turned out to be. We forget the details from back then, but JnJ had a few stumbles out of the gate that if they were avoided could have put them closer to even with the other 2 for total people vaccinated.
A J&J rep around here with structural heart is a Moderna recipient. His stories about the gate stumble and “shop talk” around what happened are fascinating. Not alarmist, just intriguing.
 

Heppenheimer

Well-Known Member

Since the beginning of the pandemic, doctors have found that people who become very ill with Covid-19 often experience kidney problems, not just the lung impairments that are the hallmark of the illness.

Now, a large study suggests that kidney issues can last for months after patients recover from the initial infection, and may lead to a serious lifelong reduction of kidney function in some patients.

The study, published Wednesday in the Journal of the American Society of Nephrology, found that the sicker Covid patients were initially, the more likely they were to experience lingering kidney damage. But even people with less severe initial infections could be vulnerable.

“You see really, across the board, a higher risk of a bunch of important kidney-associated events,” said Dr. F. Perry Wilson, a nephrologist and associate professor of medicine at Yale, who was not involved in the study. “And what was particularly striking to me was that these persisted.”

Kidneys play a vital role in the body, clearing toxins and excess fluid from the blood, helping maintain a healthy blood pressure, and keeping a balance of electrolytes and other important substances. When the kidneys are not working properly or efficiently, fluids build up, leading to swelling, high blood pressure, weakened bones and other problems. The heart, lungs, central nervous system and immune system can become impaired. In end-stage kidney disease, dialysis or an organ transplant may become necessary. The condition can be fatal.

The new study, based on records of patients in the Department of Veterans Affairs health system, analyzed data from 89,216 people who tested positive for the coronavirus between March 1, 2020, and March 15, 2021, as well as data from 1,637,467 people who were not Covid patients.

Between one and six months after becoming infected, Covid survivors were about 35 percent more likely than non-Covid patients to have kidney damage or substantial declines in kidney function, said Dr. Ziyad Al-Aly, chief of the research and development service at the V.A. St. Louis Health Care System and senior author of the study.
Acute renal failure is pretty common after shock, from sepsis or other causes, so this isn't surprising. If the patient survives, the kidney function usually recovers, although not always fully. It would be interesting to compare COVID-induced renal failure to those from other causes of spetic shock. If it is worse for COVID, it might be because of the prolonged duration of severe illness.

Also, sometimes in critical care, the kidneys get sacrificed in favor of the heart and lungs, because you can survive longer with poor (or no) kidney function and they can recover to a certain degree. Once the heart becomes overwhelmed, though... game over.

All the more reason to get vaccinated. Being dependent on dialysis to stay alive is not particularly pleasent.
 

correcaminos

Well-Known Member
Honestly I think people need to chill a little on the extra dose thing and who is best. This is why we study. Moderna and Pfizer-BioNTech both have asked for approval of dose 3. Doesn't mean they'll need it or that they will recommend to all. Could be more immunocompromised people will need 3 doses or beyond. Could mean only some brands will suggest it - Novavax for example added a 3rd in their trials. Moderna and Pfizer-BioNTech have separate studies for different levels of boosters. J&J is looking at 2 and has been from the start. Could be only 55 or 60+ need or only some brands. Could be sub 16 or 18 only need 1 or 2. I think trying to say J&J is sucky or Moderna is the best is exactly the crap that got us in this unvaxxed mess to begin with. All are amazing and if some need an extra dose or two or we all need it anually we'll figure it out. We have 2 brands in my house. Some friends have 3. All are better than none.
You may find it hard to believe, but I truly commend you for taking part. Most people don't have the balls to risk their personal health and safety for others. God Bless you for that and you have my respect. I may not agree with the process, but it does not mean I harbor ill will towards you.
Thank you. I won't lie, I was scared doing it, but early on I saw how horrible it affected people. I've shared a story of my aunt and why I joined (short if you missed: getting that call at 11pm at night saying to just pray, because you cannot be there as they struggle sucks - she survived it but died 8 months later or her neuro degenerative disorder combined with Cerebral palsy. I never wanted another to live that though I never did see her in person her last year of life). But let's be real, the unknown is scary as all get out. Someone had to do it. I react well with most vaccines and being early 40s with zero comorbidities I figured what did I have to really lose?

Curious what process do you not agree with?

I guess I’m confused about what “unblinded” means, as I thought it denotes finding out when you got the vaccine? The study she was in ensures that everyone got the vaccine, since there were several rounds of shots.
No, unblinded means it finds out if you got the real deal or placebo. I only know people who did Pfizer-BioNTech, Moderna, AZ-Oxford and J&J. But so far all followed an observer blind placebo controlled set up. Meaning only those administering the shot will verify what you got. Those getting the shot do not know what they are getting - placebo or real deal. Also those looking at the data do not know. They never mix and match. As in I didn't get 1 dose placebo and 1 real thing.

In my case Pfizer-BioNTech did a spin off trial giving a third dose after they let us all know if we got the shot or not. That third dose was blinded in the same way. Though they knew full well we'd figure it out. Once we did know, we received a letter with proof of vaccination. Now I know some places are doing multi doses straight off, so even if you got 3 shots, they'd still all the same. Unblinding means you find out if you got it. If your daughter was unblinded it's simply a yes or no. Everything I have read shows the same for your daughter. That it is a randomized, placebo-controlled study. The participant, the one who your daughter has direct contact with during appointments, and those looking at the data are all unaware of what she got. Those giving the injections obviously know, but they have little contact with the participants.

I have read that in the UK that they were allowing people to know so they could decide if they should get a different vaccine or not. Maybe that's the case here. There is little information out there comparatively. It sounds like US is not their goal at the moment but underdeveloped countries. Approval in the US is being continually delayed. I would have her contact her trial to find out the options. Hopefully places like Phillipines will approve so globally it will be on a WHO accepted list
@helenabear so the pandemic will ending soon by next year? As no more mask mandate by next year?
That's the hope... I'd say by spring given mandates by employers and such and natural immunity will drive things down.
 
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