Last April we drove from Washington State to help our daughters move to go work at WDW. It took us 63 hours, with one overnight stop in Goodland, KS. It would have gone more quickly, but a spring blizzard in Wyoming slowed us down to a crawl for about half a day. :hammer:
My wife and daughters also drove back in 2002, when our youngest began her college program. They had a couple of overnight stops with friends on that trip. Our two daughters also drove in 2003 (when our oldest daughter began HER college program), but they made a long road trip out of it, taking a couple of weeks and visiting Yellowstone, Chicago, Toronto, New England, Boston, NYC, Philadelphia, Washington, D.C., etc.
Having driven and flown from this corner of the US to the other, I can tell you that flying is much better! However, the drive was a great adventure, and I don't regret doing it. I just don't know that I'd ever want to do it again!