I live in Greensboro, NC, and it's 10 hours to Orlando driving at the speed limit. So if you're in central VA, 11-13 hours would seem doable, but I think that's close to the one-day driving limit.
There are a couple of other factors to consider. One is that you'll have to take vacation time to drive the 22-26 hours. Some peopel would be better off (financially) working all day and taking a late-afternoon flight. Second is the mileage on your car, or the cost of renting a car. Third is the number of people you'll be bringing.
I've also read that in terms of safety, driving is safer than flying for trips less than 350 miles. Over 350 miles, it's safer to fly. So from central VA, it's probably safer to fly. YMMV.
The general rule I follow is that if the flight is less than $200, and I've got only two people going, then it's better to fly. If four people are going, airline tickets would have to be around $125 to fly. Anything more than four people and it's best to drive.
Hope this helps.
Len