I actually find that flying hurts my sanity much more than driving. For us, at least, it is an hour drive to the airport, $12 per day for parking, 10 minute shuttle to the terminal, and have to get there an hour before the flight. So that's over 2 hours before the 2 hour flight even begins. A car service from our house to the airport is $70 each way, so that's even more expensive than parking. Then pay the $25 per checked bag. Take off shoes and belt, unpack computer, empty pockets, get scanned, sometimes get frisked, put back on shoes and belt, repack computer. Then sit at the gate waiting to load (which for us also usually is marked with 10 trips up to the counter to get our seats back together which somehow didn't end up together even though we booked 8 months ago and verified twice with the airline). Wait in line to load plane. Hope for overhead space. Last time we flew, we had a 5 hour delay due to maintenance, but I won't figure that in. 2 hours later, land at ORL. Either wait 20 minutes for baggage or wait 20 minutes for Magical Express to depart. 20 minute drive/ride to hotel - if car service, another $30. Airline tickets for our family are about $600.
Total cost to fly for us is about $800 (including tickets, baggage fees, parking/car service, assuming no meals needed, etc), about 8 hours of time (including drives to and from all airports and screenings, etc), and lots of stress.
Total cost for us to drive is about $300 (including gas both ways - 900 miles from our door 30mpg, a full relaxed meal each way, and snacks), 28 hours of driving (both ways), almost no stress, and some lost sleep (we trade off drivers, so we both usually end up pretty close to a full nights sleep, granted not the most restful). Additional bonus of having a car at Disney which saves us time waiting for busses.
Difference is 20 hours more to drive, but save $500 in expenses and far less stress. The added bonus of the drive is lots of family time playing car games, watching scenery, singing songs, etc. I wouldn't trade that for anything.