Mission:Space Orange is the worst ever.
Let me share my horrid experience with the ride.
I ride everything that Disney and Universal offer no problem. ToT? Easy. California Screaming? Cake. But Mission:Space Orange pill is a beast of its own. I first took the green one, no problem at all. The following day I took the orange pill, wrong move buddy!
During the ride, I almost passed out. I got cold sweats all over my body. After the ride, I couldn't walk straight and I felt so nauseated that I had to sit for a good 2 hours. After I felt better we went back to our hotel. That day I was pretty much knocked down and was on bed until the next morning.
The following day I had one of the worst migraine. It was unbearable that I thought my head was about to explode. I couldn't eat and I couldn't walk. I had nausea everytime I ate. My wife was worried like heck, so she called a doctor and he came an hour later. He did some quick tests and found no neurological finding. He told me I was not his first patient got knocked down by the ride
The third day, I felt so much better but still nauseated. Later that afternoon we went to Epcot to have a dinner. After that I decided to rest some more because I still felt weird.
I gradually felt better day by day but even after we left Disney, I still have not fully recovered. It took me about 2 weeks to completely shake it off and back to the groove.
But yeah.. never in my life I'd ride Mission Space again.