Patcheslee
Well-Known Member
Can we designate Feb 29th-31st as days for further discussion of efficacy?
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Coronavirus and Walt Disney World general discussion
- Thread starter Parker in NYC
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CaptainAmerica
Premium Member
Is AstraZeneca pretty much dead in the water at this point?On the vaccination front, it appears that another weapon may be added to our arsenal as early as some time in April. Novavax expects results from its clinical trial by the start of April and if the results are positive their plan is to apply for EUA short.y after. Their UK trial showed 89% efficacy so another highly effective vaccine in the mix possibly by May timeframe. This would be a great insurance policy against possible manufacturing delays from any of the other 3 manufacturers. They haven’t said how many doses would be available when, but the US has purchased 100M doses under the Warp Speed program.
Novavax expects U.S. trial data for COVID-19 vaccine at start of April
"We are expecting results right in the beginning of quarter two and shortly thereafter we will be filing for EUA (in U.S.)," he said at a Washington Post online event. The Novavax executive said the vaccine has shown a great "safety profile" in UK trials and the company might ask the U.S. Food...www.yahoo.com
edit: @MansionButler84 called this out already earlier.
I would like to minimize how often the virus and any mutations are exposed to someone who is vaccinated. For the same reasons that antibiotics aren't given out like candy at the first sign of infection, to avoid selecting for resistant strains.
Even with people following their current routines, there's more than enough exposure happening already.
For a vaccinated person, exposures that are most likely to lead to nothing, and hence reduce spread. Once spread is reduced enough, chances of anyone, including a vaccinated person having an interaction with the virus will be significantly less.
To head off someone doing the math to say that chances of exposure are already small, over seven thousand people in FL found out they lost that bet yesterday, just a few posts above. Instead do the math problem on how many vaccine virus mutation interactions are statistically likely before an unfavorable mutation happens. The farther we stay from that number, the better.
When some reviews of AZ is " minimal protection " from Covid, it looks not to be a big thumbs up.
Never said they shouldn't change their routine. In fact, I said the opposite -- I said it appears totally safe for people who are vaccinated to congregate with other vaccinated people, without masks.
Now, whether they can stop wearing masks in large public gatherings with people who aren't vaccinated:
That's an entirely different story. (and this isn't according to me, this is according to every expert).... So there are 3 critical reasons you can't suddenly have huge maskless public gatherings:
1. Remember, you do NOT wear a mask primarily to protect yourself. The primary reason for wearing the mask is to protect OTHER people.
We do NOT know the degree to which the vaccine prevents TRANSMISSION of Covid. More and more evidence is coming out that it does reduce transmission but the data is just starting to come in. We don't know HOW MUCH it reduces transmission.
Since this is such a huge question mark -- We need to continue masking to protect others.
2. Furthermore, there are a lot of other unknowns. We know the Pfizer and Moderna vaccines are HIGHLY EFFECTIVE in the short-term (first couple of months), against the previously dominant variants. We know they are less effective against the South African variant -- We don't really know HOW MUCH less effective.
Now, even if the vaccine becomes much less effective after 6 months.. even if it had poor effectiveness against the South African variant, and even if the SA variant grows -- It's extremely unlikely a vaccinated person would transmit it to another vaccinated person.
But, if either of those people are unvaccinated -- there could potentially be a very real risk both ways in that scenario.
3. I previously said you could immediately start to have maskless large gatherings if you required a vaccine passport -- If you guaranteed that every person present was vaccinated.
But if you don't have proof of vaccination, then you have no way of knowing who was vaccinated and who isn't.
Children don't even qualify for the vaccine but can face extremely serious complications from Covid infection, Multi-system inflammatory syndrome.
So in that large gathering mixing vaccinated adults with non-vaccinated adults with non-vaccinated children... how would you enforce a rule that only non-vaccinated people have to wear masks?? (And remember, go back to #1 -- You wear a mask to protect the people around you, you don't wear it to protect yourself).
THIS
jmp85
Well-Known Member
Wow! FACTS MATTER. For your information the experts AGREE with ME. FEBRUARY has 28 days this year!!!
Chi84
Premium Member
That's excellent.
jmp85
Well-Known Member
I'll probably get put in timeout, but this thread has gone into the gutter.
Chi84
Premium Member
And you think you are the one who should get put in time out?!
Sirwalterraleigh
Premium Member
They cancelled out till may today?
Earliest sail date is December - I’ll guess? I forget where the over/under is?
He did not...but the less mass stupidity there is, the faster you move that date up.
It’s like fastpass for the intelligent.
Disney Experience
Well-Known Member
Moderna Announces it has Shipped Variant-Specific Vaccine Candidate, mRNA-1273.351, to NIH for Clinical Study | Moderna, Inc.
Company also provides update on strategy for addressing SARS-CoV-2 variants of concern CAMBRIDGE, Mass. --(BUSINESS WIRE)--Feb. 24, 2021-- Moderna, Inc. (Nasdaq: MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, announces that it has completed manufacturing
I am sure Pfizer will be or is working on one too, because the South African variant reduces protective antibodies (and thereby may impact effectiveness)
Pfizer says South African variant could significantly reduce protective antibodies
(This February 17 story corrects headline and first paragraph to show the reduction was in the protective antibodies elicited by the vaccine, not the protection of the vaccine overall)
www.reuters.com
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Sirwalterraleigh
Premium Member
Very good indeed.Moderna Announces it has Shipped Variant-Specific Vaccine Candidate, mRNA-1273.351, to NIH for Clinical Study | Moderna, Inc.
Company also provides update on strategy for addressing SARS-CoV-2 variants of concern CAMBRIDGE, Mass. --(BUSINESS WIRE)--Feb. 24, 2021-- Moderna, Inc. (Nasdaq: MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, announces that it has completed manufacturinginvestors.modernatx.com
Flugell
Well-Known Member
Well that is definitely not the story or statistics that we have in the U.K. and to be honest I cannot fathom the reticence to use an efficient, easily administered and readily available vaccine. But maybe that means more for us so............
if the link doesn’t work correctly I apologise- have never tried to use one before!!
AstraZeneca/Oxford vaccine more effective with longer dose gap: study
AstraZeneca and Oxford University's COVID-19 vaccine is more effective when its second dose is given three months after the first, instead of six weeks, a peer-reviewed study published in The Lancet medical journal showed on Friday.
www.reuters.com
Ashes Zeneca is not even a big factor in the USA. Pfizer and Moderna ( which I received ) are the big players.Well that is definitely not the story or statistics that we have in the U.K. and to be honest I cannot fathom the reticence to use an efficient, easily administered and readily available vaccine. But maybe that means more for us so............
if the link doesn’t work correctly I apologise- have never tried to use one before!!
AstraZeneca/Oxford vaccine more effective with longer dose gap: study
AstraZeneca and Oxford University's COVID-19 vaccine is more effective when its second dose is given three months after the first, instead of six weeks, a peer-reviewed study published in The Lancet medical journal showed on Friday.
James J
Well-Known Member
- In the Parks
- No
It's mainly minimal protection from the SA variant, rather than all Covid. It's currently being rolled out in 50 countries, and for the original strain has 76% efficacy against symptomatic infection for three months after a single dose. This then goes up after the second dose.
A booster for the Autumn is being prepared to deal with the variants.
Flugell
Well-Known Member
GoofGoof
Premium Member
No clue. I think their trial is still running so it will eventually finish. Under the Warp Speed contracts I think we bought 200M doses of that one so if it gets FDA approval we have to buy the doses. If it’s too late for the US to use them I imagine they go to Covax or other countries who still need them.
JoeCamel
Well-Known Member
For it to be accepted they probably have to redo the study for our FDA to approve, by then it will be too late for this vaccine and we will be on to the variants.I wouldn’t trust Ashes Zeneca either!!
GoofGoof
Premium Member
The true beauty of the mRNA technology on displayModerna Announces it has Shipped Variant-Specific Vaccine Candidate, mRNA-1273.351, to NIH for Clinical Study | Moderna, Inc.
Company also provides update on strategy for addressing SARS-CoV-2 variants of concern CAMBRIDGE, Mass. --(BUSINESS WIRE)--Feb. 24, 2021-- Moderna, Inc. (Nasdaq: MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, announces that it has completed manufacturing
I am sure Pfizer will be or is working on one too, because the South African variant reduces protective antibodies (and thereby may impact effectiveness)
Pfizer says South African variant could significantly reduce protective antibodies
(This February 17 story corrects headline and first paragraph to show the reduction was in the protective antibodies elicited by the vaccine, not the protection of the vaccine overall)
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