Coronavirus and Walt Disney World general discussion

[MagicHappens1971]

When we were there in August, there was something jarring about the blue signs and reminders that removed so much of the theming. I understand the consistent messaging argument by having uniform signs throughout the park, but it was odd. I think I saw in another thread the brilliant idea of making the signs in WWoHP be formatted to look like Umbridge’s decrees.

Other than that, I was surprised at how much Universal was offering by means of masked, distanced M&G’s and outdoor stage shows. Though it looks like recent reports are certainly more crowded than the summer.

I expected either Ministry Warnings or something akin to Umbridge’s decree. It’s very garish and jarring, that’s really all I would have to say on that.

 

[correcaminos]

Moderna's plan for those who got the Placebo in the Phase 3 study is markedly different to Pfizer's.

Pfizer: If the subject requests to end participation in the study. That subject will be unblinded. If they received the Placebo, they will be offered the vaccine only when the supply and priority group they would fall in receives it. Though they will be first in that group. In any case after 6 months post second shot they will be unblinded.

Moderna: They will unblind the whole study. Proactively reconsented participants who received placebo will be offered the vaccine to remain in trial. They will not have to wait until their normal priority group outside of the study would come up. Moderna's participants are composed of 25% healthcare workers in any case.

Interesting. I thought they were saying they'd have to wait to get approval for the unblinding and such. At least I thought I read that in a communication a while ago. So I am surprised that Modernas had an answer so quickly. Kind of wish Pfizer would alter theirs now though but maybe they will change. The idea of moving over is already nice though.

 

[Disney Experience]

Interesting. I thought they were saying they'd have to wait to get approval for the unblinding and such. At least I thought I read that in a communication a while ago. So I am surprised that Modernas had an answer so quickly. Kind of wish Pfizer would alter theirs now though but maybe they will change. The idea of moving over is already nice though.

https://www.bloomberg.com/news/arti...fer-covid-shots-to-volunteers-who-got-placebo

I believe it came up in the meeting today, but they did not agree to put any constraints on Moderna's unblinding plan.

The doctor from Stanford University is a strong advocate of a blinded crossover, but neither study is doing that.

 

[GoofGoof]

.....apparently Oxford considers the second shot a ”booster”. From the attached article:

"The booster doses of the vaccine are both shown to induce stronger antibody responses than a single dose, the standard dose/standard dose inducing the best response," the university said in a statement.

Early data show two doses of Oxford/AstraZeneca vaccine provoked good immune response

Oxford University's COVID-19 vaccine candidate has a better immune response when a two full-dose regime is used rather than a full-dose followed by a half-dose booster, the university said on Thursday, citing data from early trials. The developers of the vaccine candidate, which has been...

www.yahoo.com

 

[Disney Experience]

The successful results from Pfizer and Moderna are having a predictable impact on other vaccine trials, with some deciding not to try to get FDA approval because the US market will be too crowded with effective vaccines.

https://www.bloomberg.com/news/arti...pfe-moderna-mdrn-leave-little-room-for-others

 

[JoeCamel]

.....apparently Oxford considers the second shot a ”booster”. From the attached article:

"The booster doses of the vaccine are both shown to induce stronger antibody responses than a single dose, the standard dose/standard dose inducing the best response," the university said in a statement.

Early data show two doses of Oxford/AstraZeneca vaccine provoked good immune response

Oxford University's COVID-19 vaccine candidate has a better immune response when a two full-dose regime is used rather than a full-dose followed by a half-dose booster, the university said on Thursday, citing data from early trials. The developers of the vaccine candidate, which has been...

www.yahoo.com

Maybe just the AstraZeneca second dose is called a booster and the others are second doses?

 

[GoofGoof]

The successful results from Pfizer and Moderna are having a predictable impact on other vaccine trials, with some deciding not try to get FDA approval because the US market will be to crowded with effective vaccines.

https://www.bloomberg.com/news/arti...pfe-moderna-mdrn-leave-little-room-for-others

Realistically, if the JnJ results are good and their vaccine gets approved the US could have enough doses to vaccinate 250 to 300 million people by May or June. Likely more than demand even if children are approved. If AstraZeneca is approved too that would make it almost certain that supply will be higher than demand before the end of June. Demand is not likely to exceed 75-85% of the total population so 250 to 280 people to vaccinate at most. I agree with the article that there’s still going to be need and demand outside the US. Plus the ones that got pre-orders from the US, UK and EU just need to get their vaccines approved then they have guaranteed sales even if not needed. Then it’s up to those nations to donate or sell the excess doses to poorer countries.

 

[Disney Experience]

Another way of looking at the efficacy of the Moderna vaccine than the final Primary Efficacy Percent of 94.1% is to look at the incident rate per 1000 person years (As was presented in a slide during the presentation).

It is the same info but just a different way to get an idea of how good it is:
Moderna's Vaccinated Group Incidences: 3.3 per 1000 person years.
Moderna's Placebo Group Incidences: 56.5 per 1000 person years.

 

[Disney Experience]

Some countries are very serious about Covid restriction, especially when keeping it under control is vital to their tourism and economy.

Eighteen year old medical student slipped off her iMsafe wristband to watch her boyfriend's Jet Ski competition.

She was sentenced to four months in jail in the Cayman Islands.

Skylar and VJ jailed after appeal : Cayman News Service

caymannewsservice.com

Cayman Islands: the latest coronavirus counts, charts and maps

Tracking the COVID-19 outbreak, updated daily

graphics.reuters.com

 

[danlb_2000]

FDA Vaccine and Related Biological Products Advisory Committee Meeting results:

"Based on the totality of scientific evidence available, do the benefits of the Moderna COVID-19 Vaccine outweigh its risks for use in individuals 18 years of age and older?"

Yea: 20
Nay: 00
Abstain: 01

There one one abstention on the Pfizer vote also, anyone know the story behind that?

 

[sullyinMT]

Another way of looking at the efficacy of the Moderna vaccine than the final Primary Efficacy Percent of 94.1% is to look at the incident rate per 1000 person years (As was presented in a slide during the presentation).

It is the same info but just a different way to get an idea of how good it is:
Moderna's Vaccinated Group Incidences: 3.3 per 1000 person years.
Moderna's Placebo Group Incidences: 56.5 per 1000 person years.

Pretty impressive. In my state of Montana, there are about 1070 “person years” per year. At 3.3 cases/1000 py works to ~10 cases per day state wide if 100% vaccinated. Quick estimated math on Florida works out to ~200 daily cases, and ~3k nationally. If those numbers of efficacy hold, even 75-80% usage rate will be a rather impressive change in the situation. A point could be reached where contact tracing and testing should snuff out what’s left.

 

[sullyinMT]

Some countries are very serious about Covid restriction, especially when keeping it under control is vital to their tourism and economy.

Eighteen year old medical student slipped off her iMsafe wristband to watch her to attend her boyfriend's Jet Ski competition.

She was sentenced to four months in jail in the Cayman Islands.

Skylar and VJ jailed after appeal : Cayman News Service

caymannewsservice.com

Cayman Islands: the latest coronavirus counts, charts and maps

Tracking the COVID-19 outbreak, updated daily

graphics.reuters.com

And folks don’t think vaccination will be mandatory to cruise, no exceptions? Here’s exhibit A (for today).

 

[MisterPenguin]

The Reduced Shipment: A Tragedy in One Act as summarized from the New York Times with numbers altered for artistic license.

Operation Warp Speed (OWS): Hey, Pfizer, send the states 70 boatloads of vaccine every week.​

​

Pfizer: OK!​

​

States: Yeah!​

​

<time passes>​

​

States: Um, hey, on this second week, we only got 30 boatloads, what gives?​

​

OWS: ....​

​

Pfizer: ...​

​

States: Hey!!​

​

OWS: Yeah, Pfizer, what's up with shorting the states?​

​

Pfizer: We have plenty of boatloads of shipments ready to go. We only follow OWS's lead.​

​

OWS: We didn't say to short the states.​

​

Pfizer: You told us to deliver 4 days earlier than normal, and we couldn't get a full shipment out with just three work days.​

​

OWS: Oh, yeah. It was the states that said they wanted the shipments earlier.​

​

States: Oh, yeah, we did. But you didn't tell us it would result in a reduction the week the earlier schedule started.​

​

OWS: How were we supposed to know that? Pfizer didn't tell us.​

​

Pfizer: What did you expect? Look, here's the shipment number for next week which is especially large because it has the boatloads we couldn't ship this week plus the usual week's boatloads.​

​

OWS and States: Oh.​

​

finale​

 

[Disney Experience]

There one one abstention on the Pfizer vote also, anyone know the story behind that?

He was uncomfortable with the language. He felt it was too broad in allowing all ages in the EUA vs just the targeted high risk group. That the risk benefit ratio for non high risk groups did not warrant inclusion in the EUA during a pandemic and limited quantities. He wanted the EUA to only target high risk groups and not the general population.

 

[Disney Experience]

Pretty impressive. In my state of Montana, there are about 1070 “person years” per year. At 3.3 cases/1000 py works to ~10 cases per day state wide if 100% vaccinated. Quick estimated math on Florida works out to ~200 daily cases, and ~3k nationally. If those numbers of efficacy hold, even 75-80% usage rate will be a rather impressive change in the situation. A point could be reached where contact tracing and testing should snuff out what’s left.

Plus no one in the vaccine group died with covid19 or had a severe case of Covid19. One person in the placebo group died, Age 54 with diabetes.

 

[TrainsOfDisney]

Some countries are very serious about Covid restriction, especially when keeping it under control is vital to their tourism and economy.

Eighteen year old medical student slipped off her iMsafe wristband to watch her boyfriend's Jet Ski competition.

She was sentenced to four months in jail in the Cayman Islands.

Skylar and VJ jailed after appeal : Cayman News Service

caymannewsservice.com

Cayman Islands: the latest coronavirus counts, charts and maps

Tracking the COVID-19 outbreak, updated daily

graphics.reuters.com

She had the typical American mentality... I can do whatever I want and the rules don’t apply to me.

 

[Chip Chipperson]

She had the typical American mentality... I can do whatever I want and the rules don’t apply to me.

She'll make a great politician some day.

 

[DCBaker]

 

[oceanbreeze77]

HOLY...please dont let the reason be what I think it is....

SO it looks like this might actually be the reason.

 

[carolina_yankee]

Because? That’s a pretty serious allegation without a link.