The only single closure that could make me consider canceling a whole trip would be Haunted Mansion.
But I also need some combination of most of the following: Spaceship Earth (I'll visit during the 2-year refurb, if that's still a thing, but I won't be too happy about it), Living with the Land, monorail, Splash Mountain (but I often visit in winter despite seasonal rehabs, so that's no dealbreaker), Country Bears, Peoplemover, Carousel of Progress, and Flight of Passage.
I've happily gone on entire Orlando trips where I didn't set foot in Hollywood Studios. I like ToT, Echo Lake, and the Muppets, but I can skip all that and not feel I'm missing too much. RotR is great, but (now that I've done it a couple times) the boarding groups are such a pain that it's almost not worth it anyway.
That said, I was waiting for Ratatouille to open before my next trip, so I'll want that and the other new rodent-themed ride to be available.