I am in New Orleans so getting to Orlando by train is not an option (at least with any reasonable connection). But as an example, to get from New Orleans to Charlottesville VA:
14.5 hour drive, approximately $150 gas in my Yukon
4 hour connecting flight, $230
24.5 hour train (if on time), roomette so can hopefully sleep some of the 24 hours, $411
It just never makes sense in any scenario I've ever checked to take Amtrak long distances unless just for the experience...close to twice as much as flying and 6x as much time. On my hypothetical trip 2 full 24 hour days of travel are required to get back and forth.
As I said, I love trains (especially in Europe) and we use the regional trains to get to and from Washington DC and my wife's father's house in Virginia all the time. They are comfortable, spacious and the stress level is so low. But I just can't make them work for anything over a couple of hours. The time/money ratio just doesn't work for me.