Vegas Disney Fan
Well-Known Member
Antibodies and cells are something I never thought I’d know so much about (which is still an elementary understanding) but they sure are fascinating.Sort of, but not quite. The memory T and B cells that remain are sort of like a pool of reservists that were never called up. Once the cell matures and actually starts fighting the specific antigen for which it was selected, it has a limited life span.
That pool of reservists that remains is what goes dormant. But even this pool diminishes slowly over time (for those who took chemistry, it declines predictably via 1st order kinetics). It never goes to completely zero, but it might diminish far enough that the remaining numbers are inadequate to respond to an infection. This is why we receive boosters for most vaccinations.
It's not really a matter of "memory", these are single cells that have no nervous system. However, a variable portion of their genetic code just so happens to produce the correct antibody that is needed to fight a specific infection. This is the reason that their stem cell "ancestor" was selected and allowed to form a clone army of itself. When that same infection arrives again, a portion of these memory cells get "called up to active duty", where they then differentiate into their mature forms.
As a side-bar, I've been reading about why certain vaccines and infections seem to stimulate much longer protection than others, apart from the issue of their targets mutating. It's complicated, but according to the most likely theory, it depends on the number leukocyte of stem cells stimulated by the initial infection and/or vaccination. Even though the cells are selected through random chance, certain configurations in the target (the infection or vaccine) are more likely to generate a more robust response. For whatever reason, the specific antigens on the measles virus (or vaccine) just happen to stimulate a much larger number of matching stem cells than conditions like pertussis or COVID. Also, children have a much larger population of immune stem cells than adults. This is part of the reason why it makes sense to start most vaccine series in children. It also suggests that when we finally have COVID vaccines for young children, barring further antigenic drift of the virus through mutation, they may need boosters less frequently than adults.
I became EMT certified in college and those courses fascinated me just as much, the human body is mind boggling.