100th verse, same as the first!
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Coronavirus and Walt Disney World general discussion
- Thread starter Parker in NYC
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- coronavirus covid covid-19
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Great idea. Maybe give your immune system some direction on what to do, give it a head start so it can respond as fast as possible. Something like an Ikea sheet showing how to fight off COVID.
Deep, man. But I’d say it just exposed the actions and intents of people in power to anyone who wasn’t paying attention.
Wendy Pleakley
Well-Known Member
Of all the dumb talking points out there, "I have an immune system" has to be at, or near, the top of the list.
People die every day from various illnesses. They had immune systems too.
People die every day from various illnesses. They had immune systems too.
Who wants to start a thread glossary? A 25-volume set.
Heppenheimer
Well-Known Member
This is good news and a useful tool to have in our arsenal, but this drug will not get us out of the pandemic. At best, paxlovid will relieve some of the pressure on hospitals. From what I read in the supporting literature, it looks like there was about a 78% reduction in hospitalizations in the treatment versus the placebo arm, and zero all-cause mortality deaths vs 12 in the placebo group during the approximately month long observation period. Interesting that 47% of the trial participants were "serologically negative", meaning either they were unvaccinated, without prior infection, or their existing immunity from either source faded completely (less likely, though).The FDA has issued an EUA for Pfizer's COVID antiviral pill -
"Today, the U.S. Food and Drug Administration issued an emergency use authorization (EUA) for Pfizer’s Paxlovid (nirmatrelvir tablets and ritonavir tablets, co-packaged for oral use) for the treatment of mild-to-moderate coronavirus disease (COVID-19) in adults and pediatric patients (12 years of age and older weighing at least 40 kilograms or about 88 pounds) with positive results of direct SARS-CoV-2 testing, and who are at high risk for progression to severe COVID-19, including hospitalization or death. Paxlovid is available by prescription only and should be initiated as soon as possible after diagnosis of COVID-19 and within five days of symptom onset.
“Today’s authorization introduces the first treatment for COVID-19 that is in the form of a pill that is taken orally — a major step forward in the fight against this global pandemic,” said Patrizia Cavazzoni, M.D., director of the FDA’s Center for Drug Evaluation and Research. “This authorization provides a new tool to combat COVID-19 at a crucial time in the pandemic as new variants emerge and promises to make antiviral treatment more accessible to patients who are at high risk for progression to severe COVID-19.”
Paxlovid is not authorized for the pre-exposure or post-exposure prevention of COVID-19 or for initiation of treatment in those requiring hospitalization due to severe or critical COVID-19. Paxlovid is not a substitute for vaccination in individuals for whom COVID-19 vaccination and a booster dose are recommended. The FDA has approved one vaccine and authorized others to prevent COVID-19 and serious clinical outcomes associated with a COVID-19 infection, including hospitalization and death. The FDA urges the public to get vaccinated and receive a booster if eligible. Learn more about FDA-approved or -authorized COVID-19 vaccines.
Paxlovid consists of nirmatrelvir, which inhibits a SARS-CoV-2 protein to stop the virus from replicating, and ritonavir, which slows down nirmatrelvir’s breakdown to help it remain in the body for a longer period at higher concentrations. Paxlovid is administered as three tablets (two tablets of nirmatrelvir and one tablet of ritonavir) taken together orally twice daily for five days, for a total of 30 tablets. Paxlovid is not authorized for use for longer than five consecutive days."
More at the link below -
Coronavirus (COVID-19) Update: FDA Authorizes First Oral Antiviral for Treatment of COVID-19
Today, the FDA issued an EUA for the first oral antiviral for treatment of COVID-19 in adults and pediatric patients.www.fda.gov
The medication is only authorized for those considered "high risk of hospitalization", but I noticed they included anyone with a BMI above 25 in that list, so effectively most adults living in the western world will probably meet the eligibility criteria. I'm pretty sure the criteria is a BMI above 30 for the monoclonal antibody, so more people will likely qualify for this oral treatment than for the infusion.
Like tamiflu, this medication needs to be given as soon as possible after symptoms develop. With the availability of at-home tests for COVID, this should make it much easier to hit the eligible population in the proper time window.
Now, the all-important caveats. Unlike the very rare incidence of severe side effects in the vaccines, protease inhibitors tend to have some rather significant toxicities. This might not be a huge issue, because we usually see these side effects with chronic use of the medications in HIV patients, and the prescribed course of paxlovid is relatively short. We'll probably only get a better handle of this as the medication becomes more widely administrated in the general population.
The other surprising caveats were some of the drug interactions that will contraindicate paxlovid use. Some of these drugs are fairly common, such as alfuzosin, amiodarone, flecanide, carbamazepine, phenytoin, lovastatin, simvastatin, salmeterol, and even sildenafil (aka, viagra). Some of the contraindicated medications can probably be stopped temporarily, but someone taking amiodarone and flecanide for a heart arrhythmia, carbamazepine or phenytoin for seizures, or sildenafil for pulmonary hypertension can't just stop these medications without potentially severe consequences. So, some of the people who are sickest and most vulnerable at baseline may not be able to take paxlovid.
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Walmart delivery just arrived with what feels like the last at home tests anywhere in the area. Scooped them up from the porch before something happened. Now, the website shows nothing for delivery and nothing in any nearby store. Three boxes and we're going to use two prior to visiting some family. The instinct to hoard and regret of not ordering six boxes is strong.
This should come in handy, they are slightly harder to use than a pregnancy test.
xkcd.com
Here's hoping for solid red.
This should come in handy, they are slightly harder to use than a pregnancy test.
Rapid Test Results
Here's hoping for solid red.
Walmart delivery just arrived with what feels like the last at home tests anywhere in the area. Scooped them up from the porch before something happened. Now, the website shows nothing for delivery and nothing in any nearby store. Three boxes and we're going to use two prior to visiting some family. The instinct to hoard and regret of not ordering six boxes is strong.
This should come in handy, they are slightly harder to use than a pregnancy test.
Rapid Test Results
Here's hoping for solid red.
I'm behind the times.
All I'm getting delivered today is perfume and a pair of shoes!
We have no tests in stock around us, but honesty we aren't looking to buy any. We are just seeing immediate family on Friday (that we see all the time), all of which are vaccinated and boosted. If I felt sick I would go get a test, but I don't.
Incomudro
Well-Known Member
Well, a good portion of society, particularly US society is composed of people who are unhealthy, physical messes, mostly due to their lifestyle habits.
Covid exposed that.
Mitigation measures have actually increased many of the components that make people vulnerable to covid.
Ayla
Well-Known Member
In some places, we are starting to see a replay of March 2020. Churches are canceling in-person Christmas services, Broadway is closing shows, businesses are having to close because they don't have enough healthy staff, pro sports are being affected by players being out, etc.
Ayla
Well-Known Member
Thank you for breaking things down and explaining them in a way us non-doctors are able to easily understand. It is much appreciated.
Epcotfan21
Well-Known Member
International travel for sure. Continental most likely too.
Ayla
Well-Known Member
Has there been any whisperings of bans on international travel?
mf1972
Well-Known Member
i’ve had 2 nurses i work with (different shifts) who have both tested positive. they were vaccinated but i don’t know if they were boosted. 1 of them is 3-4 months pregnant but i hear she’s doing ok. i’ve had 2 other coworkers rail against the mandate when it was announced & vowed to get an exemption. 1 came around & got vaccinated, the other got the exemption.
we’ve had all sorts of covid patients come through my dept. adults, kids, babies, even pregnant women. some cases aren’t that bad, but the bad ones are another story. covid isn’t going anywhere anytime soon. i just hope people will come around & do the right thing. have a safe & merry christmas everyone.
we’ve had all sorts of covid patients come through my dept. adults, kids, babies, even pregnant women. some cases aren’t that bad, but the bad ones are another story. covid isn’t going anywhere anytime soon. i just hope people will come around & do the right thing. have a safe & merry christmas everyone.
Epcotfan21
Well-Known Member
Not that I’m aware of. I just think most individuals won’t want to come to a place that’s going to have 30k+ cases in the state each day. And that’s only the people that actually will go get tested at a site. The real number will be closer to 50k+ cases each day for the next two months.
Vegas Disney Fan
Well-Known Member
I can’t imagine working in a hospital and not being vaccinated. I was very hesitant to get the vaccine until the day they announced we were going back to work, the thought of being around hundreds of people a day was enough to convince me.
The thought of health care professionals being unvaccinated around hundreds of Covid positive people everyday is mind boggling.
Chip Chipperson
Well-Known Member
Sure, but those people were weak and lacked the courage to fight their oppressors!
That's not true though. With so many countries talking about closing it's not even a little off the table and under this administration it would actually be enforced. Also until mandatory proof of vaccinations must to go anywhere is a must
Vegas Disney Fan
Well-Known Member
A few “safe re-election” states may do it but the national forecast already looks tough for the House and Senate in 2022, this would seal their defeat.
We might see some capacity limits again, maybe 6 feet distancing again, but a 2020 shutdown would be political suicide, it won’t happen purely for political reasons.
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