If you have your own car and one adult can be designated driver, then driving makes the most sense. If you're going in two weeks it'll probably be hot. Not summer-hot but hot enough that, whatever you're doing during the day, it'd be good to go back to your resort, clean up and put on fresher clothes, and drive over. If you opt to use Disney transportation, then some service lines will make more sense than others - example, if you're staying at AKL, it makes more sense to bus to AK or MK, then bus (or at MK, you have the option of boating) to WL. But however you use WDW transportation to get there, it will undoubtedly be longer than driving, and then you have to factor the time of going back.
Now, if you don't mind going straight to WL from a park, then sure when you're ready to go, jump on a bus to WL. When you're done, bus or boat back to MK and then hop on another bus there to get back to your resort. Advantage this way - if you wanted to spend more time exploring WL before or after dinner, you've got it. It's just a question of how comfortable you'd feel sitting down for a nice(-ish) dinner without cleaning up first. Personally, even if I have to "power wash" with a 30-second shower, I want to put on clean clothes for dinner; I've spent the day sweating and slathering on sunscreen, it's nice to peel some of that off first.