Of my 43 trips, at least 25 of them were driving from Vermont. Personally it didn't really matter. When on a vacation trip the entire experience is what I enjoy. I love road trips, but have to admit that as I got older the trip seemed longer and longer. Part of the reason we were able to do it so often was that we never tried to marathon it. We would, after the first trip, leave Vermont on Saturday morning (early) and drive through to Fredricksberg, Va. Stayed over-night and then traveled to Walterboro, S.C., stopped and then drove from there to Kissimmee the next day arriving about 2 pm on Monday. We made many stretch stops along the way and I loved the entire trip. But that's just me.
I know others that go 3 to 4 times a year and drive because they always bring their cats. They drive straight through. I don't know how that is done without killing yourself. And how do they have the energy to do anything once they get there. Others won't drive at all, but, will fly down. I did that in later years when I was single, but, previous to that the cost of flying the entire family down plus renting a car was just to expensive.