I've never felt unsafe at Pop. I stayed there on my first trip ever that wasn't with my parents when I was 18 with a friend who was also 18. I'm currently at Pop on a solo trip. I was just having a conversation with a friend that I stayed at a Double Tree Hilton in Anaheim when I went to Disneyland and paid about the same for that that I paid for Pop, and the room at Pop is 10x nicer. The only thing I request is to not be on a first floor since I am a solo female traveler, but that would be the case in any hotel that had an exterior patio or entrance. The worst thing about Pop is that it's a bit noisy, but that can be true of any large hotel, or one located near a highway.
If you want to do Uni, stay at Uni. If you want to do Disney, stay at Disney. The convenience of being at Disney and being able to hop on Disney transportation and be back at your hotel is unbeatable. That being said, if I were doing Uni, I would absolutely be staying over there for the same reason.
Room at Pop...
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I love that shower; it's so nice.