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Israel has been doing boosters for those 60 and older, according to an unreleased study it is providing significant increase in protection. https://www.reuters.com/world/middle-east/israel-finds-covid-19-vaccine-booster-significantly-lowers-infection-risk-2021-08-22/

Here is an article that summarizes a lot of the papers/studies that provide the basis for the decision moving forward with boosters for the general public. The article includes links to many of the papers. https://www.medpagetoday.com/infectiousdisease/covid19vaccine/94106

I am still amazed at the responses I personally hear when talking with people ( not online ). Most of these people I am on friendly terms, and try to understand their point of view. Most seem to be prideful or emotional defensive when the topic comes up. Here is a small example: Coworker...

https://www.medrxiv.org/content/10.1101/2021.08.06.21261707v2

https://www.cdc.gov/mmwr/volumes/70/wr/mm7034e3.htm

The press briefing that broadly touches on what data drove the decision to move towards boosters for all. https://www.whitehouse.gov/briefing-room/press-briefings/2021/08/18/press-briefing-by-white-house-covid-19-response-team-and-public-health-officials-50/

True.

Vaccine effectiveness is quoted is relative terms not absolute. I gave VE relative numbers not absolute numbers . ( See prior posts where I even described the use of it in studies). The minimum VE in relative numbers that the FDA would have initially approved at the start of the pandemic was...

If I had not caught Delta in June, according to when I was fully vaccinated in September 2020, the expected VE (efficacy) against wild covid (ie original covid) would be 63% right now for me. 63% is not slightly less. So almost a coin flip. If you factor in the decrease in VE from delta it...

Lots of data showing vaccines wearing off. Just look at some of the studies and analysis I have linked in the past. This includes Pfizer’s own analysis of phase 3 data pre delta. VE of Pfizer is dropping 3% per month. ( linked in the past) Then other studies showing Pfizer is less effective vs...

For those that have animals or are concerned about animal being vectors for covid, Zoetis ( Pfizer used to be a majority stockholder) has PCR test for animals as well as vaccines. https://www.zoetisus.com/misc/files/pdfs/dxtestingprotocol.pdf...

https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-submission-initial-data-us-fda

Technically I believe the Phase 3 Pfizer study report had 84% at 4+ months ( before Delta was prevalent ). I linked the study a while back. Delta will make VE less than that. About a 3% drop per month was reported in study pre-delta.

They also used absolute risk reduction instead of relative risk reduction. Using absolute risk has value and have read papers contrasting it to relative risk. But when they downplay a vaccine’s effectiveness because it only had a 5% ARR (Absolute Risk Reduction), I believe they chose to use it...

When I was in boot camp age 17 one of the first of the volunteer army (vs draft era ) ( a few years after Vietnam war ended ) I was walking down the hall in sick call ( I was later diagnosed with walking pneumonia and shipped to hospital) . Going the other way was an officer. He had medals all...

A study showing that vaccination in a country does reduce SARS-CoV-2 mutation rate. ( Not yet peer reviewed) https://www.medrxiv.org/content/10.1101/2021.08.08.21261768v1

Another study showing that in Israel that time since vaccination is positively correlated to risk of infection.( How positive does vary by age group ). There can be confounding factors ( demographics of who was vaccinated when, who takes a PCR test, etc.). Study data is from May through July so...

Funny thing in my vaccinated moderate case I had no nasal congestion ever.( obviously there was virus in nasal cavities since swabs were positive) . Instead it started in my throat ( perhaps initial particles were mouth breathed in, ( singing in church) and quickly progressed to lungs. June...

One interesting issue with non-clinical studies is that the reference level of neutralizing antibodies is based on the amount needed as shown in studies of primates to neutralize the original wild SARS-CoV-2, not delta. I expect they will do a new primate study someday against delta to give a...

Albeit small , but randomized trial shows that a third moderna shot in transplant recipients provides adequate neutralizing antibodies ( two shots do not provide enough neutralizing antibodies) . Study: https://www.nejm.org/doi/full/10.1056/NEJMc2111462 Separate letter...