I am not aware of any studies on saline, but I do know of a few on the use of the Neti Pot which is similar. It works in terms of a sinus congestion and in prevention of chronic sinus infections, but with an exception. In regards to chronic sinus infections, you can use it too much causing worse and/or more frequent sinus infections. If you use it too much you wash away too much mucus and leave yourself completely unprotected to bacteria and viruses. The magic number seems to be no more than 3 times per week. I would assume that saline spay can be used more frequently as the volume of water going through your sinuses is drastically less.