if you're driving from Ohio, I presume you'll be taking 75 down. 75 Southbound - Florida's Turnpike Southbound - 4 Westbound will get you to WDW. Watch out for traffic in Atlanta- it can get nasty.
The Autotrain goes from Lorton, VA (next to DC) - Sanford, FL (next to Orlando).
The 528 Beeline (aka- Beachline) is the Toll Road that goes from Orlando to Cocoa Beach. On a good day, it should take you less than 45 minutes to complete the drive from A-B. On an EXTREMELY, HORRIFICALLY bad day, 90 minutes. The 520 is a local road the runs the same route, but will take you considerably longer.