Well, they aren't getting rid of the Muppets area, so Star Tours would be close by but separated from Star Wars Land by the Muppets land. It could stay the same, as it has proven to be a successful standalone ride, or be rethemed.
It would define the stay if, in the future, they got rid of the Muppets land, replaced it with more Star Wars Land, and themed Star Tours to be the major space port of whatever city SWL is set in, which would allow it to be the exact same ride. But I bet that won't happen.
It will no doubt end up being rethemed, this is where a Guardians OTG ride could fit, it would still be space themed of course, you would still be supposed to be going on a commercial flight, before ending up in a battle. Or you could be in a ship which is trying to save the Guardians from who knows what.
There isn't really anywhere for Guardians to go elsewhere, other than TOT of course, so this would house them, and even be the entrance to a future Marvel Land.