Cars are one of my passions.
Mazda's shot up dramatically in reliability since they ditched Ford, and were allowed to develop their own cars. They recently topped Consumer Reports.
The most reliable Japanese brands are Mazda, Toyota, and Lexus.
Honda and Acura are generally good, but their reliability began to slip as they replaced their normal automatic transmissions with CVTs, which by their design have longevity and reliability issues. They followed Subaru and Nissan down the CVT rabbit-hole, which tarnished their reputation for reliability. (Manual transmission Hondas though are generally good cars, but not relevant to this discussion).
Within American cars, reliability generally won't be as high as Mazda/Toyota/Lexus. They'll usually fit in a right between Japanese and European cars (some models are outliers though) in reliability (but a bit lower in fit/finish), but the parts costs and availability with generally be cheaper than any import.
Also, there's Kia/Hyundai - the Hyundai Palisade is getting great reviews, as is the Kia Telluride. And as long as the car is maintained at the dealer, the warranty is excellent.